A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions
doi: 10.11804/NuclPhysRev.20.01.042
- Received Date: 1900-01-01
- Rev Recd Date: 1900-01-01
- Publish Date: 2003-03-20
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Key words:
- heavy ion /
- mammalian cell /
- radiosensitivity /
- mechanism
Abstract: Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...
Citation: | LI Wen-jian, ZHOU Guang-ming, WEI Zeng-quan, WANG Ju-fang, LI Qiang, DANG Bing-rong, XIE Hong-mei. A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions[J]. Nuclear Physics Review, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042 |