Study on the Mechanism for Danggui Anti-carbon Ion Radiation Based on Network Pharmacology

PU Li; WANG Luyao; XIN Zhijun; QU Ying; WANG Jie; LI Xuehu; WU Qingfeng; WANG Yibo; ZHOU Libin; WANG Zhuanzi

doi:10.11804/NuclPhysRev.41.2023036

Volume 41 Issue 2

Jun. 2024

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Nuclear Physics Review > 2024 > 41(2): 731-741. > DOI: 10.11804/NuclPhysRev.41.2023036

PU Li, WANG Luyao, XIN Zhijun, QU Ying, WANG Jie, LI Xuehu, WU Qingfeng, WANG Yibo, ZHOU Libin, WANG Zhuanzi. Study on the Mechanism for Danggui Anti-carbon Ion Radiation Based on Network Pharmacology[J]. Nuclear Physics Review, 2024, 41(2): 731-741. DOI: 10.11804/NuclPhysRev.41.2023036

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Study on the Mechanism for Danggui Anti-carbon Ion Radiation Based on Network Pharmacology

PU Li^{1, 3,},
WANG Luyao⁴,
XIN Zhijun^{1, 2},
QU Ying^{1, 2},
WANG Jie^{1, 2},
LI Xuehu^{1, 2},
WU Qingfeng^{1, 2},
WANG Yibo³,
ZHOU Libin^{1, 2, ,},
WANG Zhuanzi^{1, 2, ,}

1.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
2.
University of Chinese Academy of Sciences, Beijing 100049, China
3.
Biological Engineering and Technology College, Tianshui Normal University, Tianshui 741000, Gansu, China
4.
The First Clinical Medical College, Shanxi Medical University, Jinzhong 030607, Shanxi, China

Funds: Crop Varietal Improvement and Insect Pests Control by Nuclear Radiation; National Natural Sciences Foundation of China (U2032139), Ecological Planting and Quality Assurance Project of Daodi Medicinal Materials (China Science and Technology for Traditional Chinese Medicine [(2020) 153]

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Corresponding author:
ZHOU Libin, E-mail: libinzhou@impcas.ac.cn

WANG Zhuanzi, E-mail: wangzz@impcas.ac.cn
Received Date: April 10, 2023
Revised Date: July 17, 2023

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Abstract

Abstract

To study the possible mechanism of Danggui anti-carbon ion radiation based on network pharmacology. The Danggui active ingredients and the targets were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and literature mining. Carbon ion radiation targets were obtained from GeneCard database. The intersection targets of the active ingredient targets and the carbon ion radiation targets were the potential targets for Danggui anti-carbon ion radiation. Active ingredients - potential targets network was constructed. Functional enrichment and pathway enrichment analysis of potential targets were performed. The protein-protein interaction (PPI) network of the potential targets was constructed and the the hub targets were obtained. Molecular docking between the hub targets and active ingredients was performed to verify the results of network pharmacology. A total of nine Danggui active ingredients and ninety-eight potential targets of Danggui anti-carbon ion radiation were obtained. The main active ingredients of Danggui anti-carbon ion radiation were ferulic acid, ligustilide, sitosterol and stigmasterol. Functional enrichment analysis showed that potential targets were primarily engaged in biological processes such as cellular stress response, inflammatory response, kinase activity, as well as molecular functions such as DNA binding, kinase binding, and nuclear receptor activity. Pathway enrichment analysis showed potential targets were mainly involved in PI3K-Akt signaling pathway, MAPK signaling pathway, etc, which interact with each other. PPI network showed that VEGFA, EGFR, CTNNB1, etc. were the hub targets of Danggui anti-carbon ion radiation. The molecular docking results showed that the active ingredient has a good binding activity to the hub targets.This study indicated that Danggui anti-carbon ion radiation was mainly through regulating inflammatory reaction, immune response, cell apoptosis and survival, and damage repair.
- carbon ion radiation,
- Danggui,
- network pharmacology,
- molecular docking

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Study on the Mechanism for Danggui Anti-carbon Ion Radiation Based on Network Pharmacology

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