In-beam PET Dose Monitoring Study of <sup>12</sup>C Tumor Radiotherapy Based on TPS and Monte Carlo Calculation

Qinghua ZHANG; Zhiqiang LIU; Dian GUO; Qiuning ZHANG; Ruifeng LIU; Changxu PEI; Jing WEN; Hongtao LUO; Shilong SUN; Chuan HUANG; Yingguo LI; Yongzhi YIN; Xiaohu WANG

doi:10.11804/NuclPhysRev.39.2021069

Volume 39 Issue 3

Sep. 2022

Turn off MathJax

Article Contents

Abstract

References

Nuclear Physics Review > 2022 > 39(3): 359-366. > DOI: 10.11804/NuclPhysRev.39.2021069

Qinghua ZHANG, Zhiqiang LIU, Dian GUO, Qiuning ZHANG, Ruifeng LIU, Changxu PEI, Jing WEN, Hongtao LUO, Shilong SUN, Chuan HUANG, Yingguo LI, Yongzhi YIN, Xiaohu WANG. In-beam PET Dose Monitoring Study of ¹²C Tumor Radiotherapy Based on TPS and Monte Carlo Calculation[J]. Nuclear Physics Review, 2022, 39(3): 359-366. DOI: 10.11804/NuclPhysRev.39.2021069

Citation:

PDF (5660 KB)

In-beam PET Dose Monitoring Study of ¹²C Tumor Radiotherapy Based on TPS and Monte Carlo Calculation

Qinghua ZHANG^{1, 2,},
Zhiqiang LIU^{2, 3, 4},
Dian GUO¹,
Qiuning ZHANG^{2, 3, 4},
Ruifeng LIU^{2, 3, 4},
Changxu PEI^{1, 2},
Jing WEN¹,
Hongtao LUO^{2, 3, 4},
Shilong SUN^{2, 3, 4},
Chuan HUANG^{1, 2},
Yingguo LI¹,
Yongzhi YIN^1, ,,
Xiaohu WANG^{2, 3, 4, ,}

1.
School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China
2.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China
3.
Lanzhou Heavy Ion Hospital, Lanzhou 730000, China
4.
University of Chinese Academy of Sciences, Beijing 100049, China

Funds: Special Fund for Basic Scientific Research Operation Fees of Central Colleges and Universities of Lanzhou University(lzujbky-2021-ct02); Talent innovation and venture project of Lanzhou city(2017-RC-23, 2020-RC-113, 2021-RC-125); National Natural Science Foundation of China(11875156); Gansu Science and Technology Department in key R&D Program(20YF8FA116); 2021 Lanzhou National High-tech Zone ``Hundred Cities and Hundred Parks'' Action Project.

More Information

Corresponding author:
Yongzhi YIN, E-mail: yinyzh@lzu.edu.cn

Xiaohu WANG, E-mail: xhwang@impcas.ac.cn
Received Date: September 26, 2021
Revised Date: November 15, 2021

Graphical Abstract

Abstract

Abstract

In-beam PET imaging provides an effective method to monitor the physical and biological dose distribution during carbon ion radiotherapy in real time. We investigate the dose distribution and In-beam PET image of a homogeneous water phantom and an abdominal tumor CT phantom by the Treatment Planning System(TPS) and Monte Carlo(MC) simulation. We compare the consistency of TPS dose distribution, the MC simulation dose distribution and the PET imaging profile at the tumor area. The relative biological effect values(RBE) were calculated using a linear quadratic model(LQ). Results show that the average error of the physical dose and RBE weighted dose in the water phantom and the abdominal tumor CT phantom were within 0.5% and 2% respectively. The carbon ion energy ranges from 120 to 400 MeV/u. The peak position difference between dose and PET imaging is within 8 mm. This paper proves the feasibility of using In-beam PET for dose monitoring during carbon ion radiotherapy.
- Carbon-ion radiotherapy,
- In-beam PET imaging,
- treatment planning system,
- dose verification

FullText(HTML)

References (14)

References

[1]	聂晶, 李贺, 李冰燕, 等. 世界复合医学, 2015, 1(03): 198. DOI: 10.11966/j.issn.2095-994X NEI J, LI H, LI B Y, et al. World Journal of Complex Medicine, 2015, 1(03): 198. (in Chinese) DOI: 10.11966/j.issn.2095-994X
[2]	肖国青, 李强, 张小奇, 等. 科技促进发展, 2020, 16(01): 9. DOI: 10.11842/chips.20200310002 XIAO G Q, LI Q, ZHANG X Q, et al. Science & Technology for Development, 2020, 16(01): 9. (in Chinese) DOI: 10.11842/chips.20200310002
[3]	叶飞, 李强. 原子核物理评论, 2010, 27(03): 309. DOI: 10.11804/NuclPhysRev.27.309 YE F, LI Q. Nuclear Physics Review, 2010, 27(03): 309. (in Chinese) DOI: 10.11804/NuclPhysRev.27.309
[4]	戴甜甜, 魏清阳. 中国医学影像技术, 2017, 33(02): 312. DOI: 10.13929/j.1003-3289.201607064 DAI T T, WEI Q Y. Chinese Journal of Medical Imaging Technology, 2017, 33(02): 312. (in Chinese) DOI: 10.13929/j.1003-3289.201607064
[5]	ENGHARDT W, CRESPO P, FIEDLER F, et al. Nucl Instr and Meth A, 2004, 525(1/2): 284. DOI: 10.1016/j.nima.2004.03.128
[6]	LI Z, FAN Y, DONG M, et al. IEEE Transactions on Radiation and Plasma Medical Sciences, 2017. DOI: 10.1109/TRPMS.2017.2769109
[7]	陈泽. In-Beam PET的性能模拟与图像重建[D]. 兰州: 中国科学院研究生院(近代物理研究所), 2014. CHEN Z. In-Beam PET Performance Simulation and Image Reconstruction[D]. Lanzhou: Institute of Modern Physics, Chinese Academy of Sciences, 2014. (in Chinese)
[8]	刘新国, 李强, 杜晓刚, 等. 原子核物理评论, 2010, 27(04): 480. DOI: 10.11804/NuclPhysRev.27.04.480 LIU X G, LI Q, DU X G, et al. Nuclear Physics Review, 2010, 27(04): 480. (in Chinese) DOI: 10.11804/NuclPhysRev.27.04.480
[9]	THIBAUT M, SIMON S, DIDIER B, et al. Physics in Medicine and Biology, 2018, 63: 18. DOI: 10.1088/1361-6560/aadac1
[10]	TOSHITO T, BSGULYA A, LECHNER A, et al. Medical Physics, 2010. DOI: 10.1002/mp.14226
[11]	FURUSAWA Y, FUKUTSU K, AOKI M, et al. Radiation Research, 2000, 154(5): 485. DOI: 10.1667/0033-7587(2000)154[0485:ioaahc]2.0.co;2
[12]	KANAI T, FURUSAWA Y, FUKUTSU K, et al. Radiation Research, 1997, 147(1): 78. DOI: 10.2307/3579446
[13]	赫捷, 王绿化, 李晔雄, 戴建荣, 等. 上海医学, 2018, 27(4): 10. DOI: 10.3760/cma.j.issn.1004-4221.2018.04.001 HAO J, WANG L H, LI H X, et al. Shanghai Medical Journal, 2018, 27(4): 10. (in Chinese) DOI: 10.3760/cma.j.issn.1004-4221.2018.04.001
[14]	付庆国, 戴建荣, 朱小东, 等. 中华放射肿瘤学杂志, 2018, 27(2): 218. DOI: 10.3760/cma.j.issn.1004-4221.2018.02.021 FU Q G, DAI J R. ZHU X D, et al. Chinese Journal of Radiation Oncology, 2018, 27(2): 218. (in Chinese) DOI: 10.3760/cma.j.issn.1004-4221.2018.02.021

Cited By

Get Citation

PDF

XML

Article Metrics

Article views (865) PDF downloads (77)

In-beam PET Dose Monitoring Study of ¹²C Tumor Radiotherapy Based on TPS and Monte Carlo Calculation

Abstract

References

Catalog

Article Metrics

Related

In-beam PET Dose Monitoring Study of 12C Tumor Radiotherapy Based on TPS and Monte Carlo Calculation

Abstract

References

Catalog

Article Metrics

Related

Export File

Citation

Format

Content

In-beam PET Dose Monitoring Study of ¹²C Tumor Radiotherapy Based on TPS and Monte Carlo Calculation