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Volume 39 Issue 3
Sep.  2022
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Zihan WANG, Hui ZHANG, Xinguo LIU, Zhongying DAI, Weiqiang CHEN, Qiang LI. Distributions of Nanodosimetric Quantities and Dose-averaged LET for Carbon Ion Beams Under Uniform Magnetic Fields[J]. Nuclear Physics Review, 2022, 39(3): 373-381. DOI: 10.11804/NuclPhysRev.39.2021052
Citation: Zihan WANG, Hui ZHANG, Xinguo LIU, Zhongying DAI, Weiqiang CHEN, Qiang LI. Distributions of Nanodosimetric Quantities and Dose-averaged LET for Carbon Ion Beams Under Uniform Magnetic Fields[J]. Nuclear Physics Review, 2022, 39(3): 373-381. DOI: 10.11804/NuclPhysRev.39.2021052
shu

Distributions of Nanodosimetric Quantities and Dose-averaged LET for Carbon Ion Beams Under Uniform Magnetic Fields

  • 1.

    School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China

  • 2.

    Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

  • 3.

    Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000, China

  • 4.

    Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province,Lanzhou 730000, China

  • 5.

    University of Chinese Academy of Sciences, Beijing 100049, China

Funds: National Key Research and Development Program of China(2018YFC0115700); National Natural Science Foundation of China(11875299, 61631001, U1532264); Key Deployment Project of Chinese Academy of Sciences(KFZD-SW-222)
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  • Corresponding author:

    Qiang LI, E-mail: liqiang@impcas.ac.cn

  • Received Date: June 20, 2021
  • Revised Date: September 21, 2021
    Graphical Abstract
    • Abstract
  • With the development of Magnetic Resonance Imaging(MRI) technology, the role and importance of image guided radiation therapy in radiation oncology are increasing rapidly. To develop the technique of MRI-guided heavy ion radiotherapy, the influence of uniform magnetic fields on the dose-averaged LET and nanodosimetric quantities of carbon-ion beams is analyzed. In this work, the GEANT4 kernel-based GATE Monte Carlo simulation platform was used to calculate the dose-averaged LET and nanodosimetric quantity distributions of carbon-ion beams with different energies under different magnetic fields. Compared to the cases without magnetic fields, it was found that the longitudinal uniform magnetic fields had little effect on the dose-averaged LET and nanodosimetric quantities of the carbon-ion beams. The influence of the lateral uniform magnetic fields on the dose-averaged LET and nanodosimetric quantities of the carbon ion beams mainly occurred in the Bragg peak regions, which was mainly caused by the lateral deflection of the carbon ion beams under the Lorentz forces in the magnetic fields, especially the lateral shift of the Bragg peak position of the carbon ion beams. These results provide a solid foundation for further study on how magnetic field affects the therapeutic performance of carbon ion beams.
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    • References (15)
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