Functions of PML in Responding to Ionizing Radiation
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Abstract
Promyelocytic leukemia (PML) plays an important role in natural immune, angiogenesis, and transcriptional regulation. It also participates in apoptosis and other radiobiological effects. We confirm that the PML expression in G1 and S phase cells is relatively higher than that in M and G2 phase cells. We also demonstrate that the expression of PML protein is up-regulated in both dose- and time-dependent manner after cells are exposed to ionizing radiation. The size and amount of PML-nuclear bodies (PML-NBs) increase in a dose-dependent manner whereas the fluorescence intensity of PML-NBs decreases. Taken together, PML is sensitive to ionizing radiation and its functional studies are facilitated to reveal the mechanisms underlying radiobiological effects.
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