A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation
doi: 10.11804/NuclPhysRev.27.02.202
- Received Date: 1900-01-01
- Rev Recd Date: 1900-01-01
- Publish Date: 2010-06-20
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Key words:
- highLET radiation /
- apoptosis /
- survivin
Abstract: It has been proven that over expression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study,action mechanisms of survivin gene in apoptosis induced by high LET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.
Citation: | Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202 |