Biological Effects of H1299 Cells Exposed to 12C Ion Beam and X rays
doi: 10.11804/NuclPhysRev.25.01.072
- Received Date: 1900-01-01
- Rev Recd Date: 1900-01-01
- Publish Date: 2008-03-20
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Key words:
- linear energy transfer /
- radiosensitivity /
- early apoptosis /
- cell cycle arrest /
- p53
Abstract: To provide basic data for heavyion cancer therapy, the biological effects of ionizing radiations with different linear energy transfers (LET) on radiosensitivity, cell cycle alteration and cell early apoptosis in H1299 cells were studied. The cell radiosensitivity was assessed by means of the standard colonyforming assay. The experimental results show that the survival fraction of H1299 cells irradiated with the 12C ions is evidently lower than that in the case of the Xrays. Moreover, compared with the Xrays the G2/M phase arrest and delay degree and the early apoptosis percentage in H1299 cells irradiated with the 12C ions were more prominent with increasing the radiation dose and repairing time. These results suggested that H1299 cells were more sensitive to 12C ion beam than Xrays. Moreover, less dose, few fractionation and longer fractionation interval were applicable to heavy ion therapy for p53 nulltype tumors.
Citation: | SU Feng-tao, LI Qiang, #, JIN Xiao-dong. Biological Effects of H1299 Cells Exposed to 12C Ion Beam and X rays[J]. Nuclear Physics Review, 2008, 25(1): 72-76. doi: 10.11804/NuclPhysRev.25.01.072 |