Specific Anti tumor Gene——Apoptin

WEI Wei; SU Xu; LI Wen-Jian; LIU Jian-Xiang; ZHANG  Hong

doi:10.11804/NuclPhysRev.22.02.229

WEI Wei, SU Xu, LI Wen-Jian, LIU Jian-Xiang, ZHANG Hong. Specific Anti tumor Gene——Apoptin[J]. Nuclear Physics Review, 2005, 22(2): 229-232. DOI: 10.11804/NuclPhysRev.22.02.229

Citation:

WEI Wei, SU Xu, LI Wen-Jian, LIU Jian-Xiang, ZHANG Hong. Specific Anti tumor Gene——Apoptin[J]. Nuclear Physics Review, 2005, 22(2): 229-232. DOI: 10.11804/NuclPhysRev.22.02.229

Citation:

WEI Wei, SU Xu, LI Wen-Jian, LIU Jian-Xiang, ZHANG Hong. Specific Anti tumor Gene——Apoptin[J]. Nuclear Physics Review, 2005, 22(2): 229-232. DOI: 10.11804/NuclPhysRev.22.02.229

Specific Anti tumor Gene——Apoptin

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Apoptin is an anticancer gene. It can induce p53independent，Bcl2insensitive type of apoptosis in various human tumor cells，and fails to induce programmed cell death in normal cell. Because of having tumor specificity， apoptin can be transferred enough to tumorcell in vivo，selectly kill the tumor as a potential antitumor biological preparation. In this paper， we provide a brief review on the anticancer mechanism of apoptin， current status and application prospect， and the main issues in apoptin studies.

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