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WEI Wei, SU Xu, LI Wen-Jian, LIU Jian-Xiang, ZHANG Hong. Specific Anti tumor Gene——Apoptin[J]. Nuclear Physics Review, 2005, 22(2): 229-232. DOI: 10.11804/NuclPhysRev.22.02.229
Citation: WEI Wei, SU Xu, LI Wen-Jian, LIU Jian-Xiang, ZHANG Hong. Specific Anti tumor Gene——Apoptin[J]. Nuclear Physics Review, 2005, 22(2): 229-232. DOI: 10.11804/NuclPhysRev.22.02.229
shu

Specific Anti tumor Gene——Apoptin

  • 1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 National Institute for Ratiological Protection, China CDC, Beijing 100088, China;3 Graduate School of Chinese Academy of Sciences, Beijing 100039, China

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  • Received Date: December 31, 1899
  • Revised Date: December 31, 1899
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    • Abstract
  • Apoptin is an anticancer gene. It can induce p53independent，Bcl2insensitive type of apoptosis in various human tumor cells，and fails to induce programmed cell death in normal cell. Because of having tumor specificity， apoptin can be transferred enough to tumorcell in vivo，selectly kill the tumor as a potential antitumor biological preparation. In this paper， we provide a brief review on the anticancer mechanism of apoptin， current status and application prospect， and the main issues in apoptin studies.
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