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王子涵, 张晖, 刘新国, 戴中颖, 陈卫强, 李强. 均匀磁场下碳离子束剂量平均LET及纳剂量学量的分布[J]. 原子核物理评论, 2022, 39(3): 373-381. DOI: 10.11804/NuclPhysRev.39.2021052
引用本文: 王子涵, 张晖, 刘新国, 戴中颖, 陈卫强, 李强. 均匀磁场下碳离子束剂量平均LET及纳剂量学量的分布[J]. 原子核物理评论, 2022, 39(3): 373-381. DOI: 10.11804/NuclPhysRev.39.2021052
Zihan WANG, Hui ZHANG, Xinguo LIU, Zhongying DAI, Weiqiang CHEN, Qiang LI. Distributions of Nanodosimetric Quantities and Dose-averaged LET for Carbon Ion Beams Under Uniform Magnetic Fields[J]. Nuclear Physics Review, 2022, 39(3): 373-381. DOI: 10.11804/NuclPhysRev.39.2021052
Citation: Zihan WANG, Hui ZHANG, Xinguo LIU, Zhongying DAI, Weiqiang CHEN, Qiang LI. Distributions of Nanodosimetric Quantities and Dose-averaged LET for Carbon Ion Beams Under Uniform Magnetic Fields[J]. Nuclear Physics Review, 2022, 39(3): 373-381. DOI: 10.11804/NuclPhysRev.39.2021052

均匀磁场下碳离子束剂量平均LET及纳剂量学量的分布

Distributions of Nanodosimetric Quantities and Dose-averaged LET for Carbon Ion Beams Under Uniform Magnetic Fields

  • 摘要: 随着磁共振成像(MRI)技术的发展,图像引导放射治疗在放射肿瘤学中的作用和重要性正在迅速增加,本研究分析了外加均匀磁场对碳离子束的剂量平均LET以及纳剂量学量的影响。通过基于GEANT4内核的GATE蒙特卡罗(Monte Carlo, MC)模拟平台,模拟计算了不同磁场环境下,不同能量碳离子束剂量平均LET和纳剂量学量的分布。结果发现,平行磁场对碳离子束的剂量平均LET和纳剂量学量均无显著影响,垂直磁场对碳离子束的剂量平均LET及纳剂量学量的影响主要集中在布拉格峰区域,其影响主要是碳离子束在磁场中受到洛伦兹力作用而发生横向偏转,进而使得碳离子束布拉格峰位置发生横向侧移导致的。这些结果为进一步研究磁场对碳离子束治疗性能的影响打下了坚实的基础。

     

    Abstract: With the development of Magnetic Resonance Imaging(MRI) technology, the role and importance of image guided radiation therapy in radiation oncology are increasing rapidly. To develop the technique of MRI-guided heavy ion radiotherapy, the influence of uniform magnetic fields on the dose-averaged LET and nanodosimetric quantities of carbon-ion beams is analyzed. In this work, the GEANT4 kernel-based GATE Monte Carlo simulation platform was used to calculate the dose-averaged LET and nanodosimetric quantity distributions of carbon-ion beams with different energies under different magnetic fields. Compared to the cases without magnetic fields, it was found that the longitudinal uniform magnetic fields had little effect on the dose-averaged LET and nanodosimetric quantities of the carbon-ion beams. The influence of the lateral uniform magnetic fields on the dose-averaged LET and nanodosimetric quantities of the carbon ion beams mainly occurred in the Bragg peak regions, which was mainly caused by the lateral deflection of the carbon ion beams under the Lorentz forces in the magnetic fields, especially the lateral shift of the Bragg peak position of the carbon ion beams. These results provide a solid foundation for further study on how magnetic field affects the therapeutic performance of carbon ion beams.

     

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