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重离子放射治疗双微小展宽峰组合照射方法

姬腾飞 刘新国 戴中颖 贺鹏博 闫渊林 黄齐艳 李强

姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强. 重离子放射治疗双微小展宽峰组合照射方法[J]. 原子核物理评论, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
引用本文: 姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强. 重离子放射治疗双微小展宽峰组合照射方法[J]. 原子核物理评论, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
JI Tengfei, LIU Xinguo, DAI Zhongying, HE Pengbo, YAN Yuanlin, HUANG Qiyan, LI Qiang. Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy[J]. Nuclear Physics Review, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
Citation: JI Tengfei, LIU Xinguo, DAI Zhongying, HE Pengbo, YAN Yuanlin, HUANG Qiyan, LI Qiang. Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy[J]. Nuclear Physics Review, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345

重离子放射治疗双微小展宽峰组合照射方法

doi: 10.11804/NuclPhysRev.33.03.345
基金项目: 国家自然科学基金委员会-中国科学院大科学装置联合基金资助项目(U1232207);国家自然科学基金资助项目(11205217,11475231,11075191);国家科技支撑计划资助项目(2015BAI01B11)
详细信息
    作者简介:

    姬腾飞(1992-),男,河南商丘人,硕士研究生,从事重离子治疗技术基础研究;E-mail:jitf@impcas.ac.cn

    通讯作者: 李强,E-mail:liqiang@impcas.ac.cn
  • 中图分类号: R815.6

Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy

Funds: NSFC-CAS Joint Fund for Research Based on Large-scaled Scientific Facilities (U1232207); National Natural Science Foundation of China (11205217, 11475231, 11075191); National Key Technology Support Program of the Ministry of Science and Technology of China (2015BAI01B11)
  • 摘要: 在基于被动式束流配送系统的分层适形重离子治疗当中,需要利用微型脊形过滤器(mini ridge filter,mini-RF)将单能重离子束Bragg峰展宽为峰区近似高斯分布的微小展宽峰(mini spread-out Bragg peak,mini-SOBP),从而达到减少照射分层数及照射时间的目的。采用较宽的mini-SOBP可以有效减少照射分层数,但会增大展宽Bragg峰(SOBP)远端剂量跌落距离,增加对靶区后方正常组织或危及器官的辐照剂量。这一问题可以通过双mini-SOBP的组合照射方法来解决。使用2种mini-RF对单能重离子束Bragg峰略微展宽得到2种半高宽(FWHM)且剂量分布近似高斯分布的mini-SOBP,通过基于放射生物学模型的剂量优化,证实了在SOBP平顶区按生物有效剂量均匀和物理吸收剂量均匀的展宽情况下,双mini-SOBP组合照射方法均可以在减少照射分层数的同时较大幅度地减小SOBP远端剂量跌落距离。

    In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.
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出版历程
  • 收稿日期:  2015-09-18
  • 修回日期:  2015-10-08
  • 刊出日期:  2016-09-20

重离子放射治疗双微小展宽峰组合照射方法

doi: 10.11804/NuclPhysRev.33.03.345
    基金项目:  国家自然科学基金委员会-中国科学院大科学装置联合基金资助项目(U1232207);国家自然科学基金资助项目(11205217,11475231,11075191);国家科技支撑计划资助项目(2015BAI01B11)
    作者简介:

    姬腾飞(1992-),男,河南商丘人,硕士研究生,从事重离子治疗技术基础研究;E-mail:jitf@impcas.ac.cn

    通讯作者: 李强,E-mail:liqiang@impcas.ac.cn
  • 中图分类号: R815.6

摘要: 在基于被动式束流配送系统的分层适形重离子治疗当中,需要利用微型脊形过滤器(mini ridge filter,mini-RF)将单能重离子束Bragg峰展宽为峰区近似高斯分布的微小展宽峰(mini spread-out Bragg peak,mini-SOBP),从而达到减少照射分层数及照射时间的目的。采用较宽的mini-SOBP可以有效减少照射分层数,但会增大展宽Bragg峰(SOBP)远端剂量跌落距离,增加对靶区后方正常组织或危及器官的辐照剂量。这一问题可以通过双mini-SOBP的组合照射方法来解决。使用2种mini-RF对单能重离子束Bragg峰略微展宽得到2种半高宽(FWHM)且剂量分布近似高斯分布的mini-SOBP,通过基于放射生物学模型的剂量优化,证实了在SOBP平顶区按生物有效剂量均匀和物理吸收剂量均匀的展宽情况下,双mini-SOBP组合照射方法均可以在减少照射分层数的同时较大幅度地减小SOBP远端剂量跌落距离。

In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.

English Abstract

姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强. 重离子放射治疗双微小展宽峰组合照射方法[J]. 原子核物理评论, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
引用本文: 姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强. 重离子放射治疗双微小展宽峰组合照射方法[J]. 原子核物理评论, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
JI Tengfei, LIU Xinguo, DAI Zhongying, HE Pengbo, YAN Yuanlin, HUANG Qiyan, LI Qiang. Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy[J]. Nuclear Physics Review, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
Citation: JI Tengfei, LIU Xinguo, DAI Zhongying, HE Pengbo, YAN Yuanlin, HUANG Qiyan, LI Qiang. Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy[J]. Nuclear Physics Review, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345
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