碳纳米颗粒的放射性<SUP>99m</SUP>Tc标记

诸颖; 李玉峰; 张小勇; 李晴暖; 李文新; #

doi:10.11804/NuclPhysRev.25.03.305

碳纳米颗粒的放射性^99mTc标记

^99mTc Labeling of Carbon Nanomaterials

摘要

摘要: 探索了影响氯化亚锡还原法制备碳纳米管和不同粒径纳米碳黑的99mTc标记化合物的多种因素，在给定实验条件下， 99mTc的标记率能够稳定达到90％以上。细胞培养液中标记物的放射化学纯度在2.5 h中保持在(86±4)%范围内。制备的标记化合物满足碳纳米颗粒细胞摄取率测定和细胞毒性机制研究的实验要求。实验结果提示， 99mTc标记过程是基于还原得到的低价Tc在碳纳米颗粒表面上的物理吸附机理。 The effects of experimental conditions on preparation of ^99mTclabeled carbon nanotubes and nanocarbon blacks by SnCl2 were investigated. At given conditions the labeling yields were over 90%. In a culture medium， the radiochemical purity of the labeling compounds kept (86±4)% within 2.5 h. The 99mTc labeled multiwalled carbon nanotubes (MWNTs) and nanocarbon blackes (NCBs) obtained in this work met satisfactory experimental demands for study of cellular uptake and toxicity. The experiments showed that the labeling process was based on physical adsorption of low valent technetium resulted from reduction reaction on the surface of the carbon nanomaterials.

Abstract: The effects of experimental conditions on preparation of ^99mTclabeled carbon nanotubes and nanocarbon blacks by SnCl2 were investigated. At given conditions the labeling yields were over 90%. In a culture medium， the radiochemical purity of the labeling compounds kept (86±4)% within 2.5 h. The 99mTc labeled multiwalled carbon nanotubes (MWNTs) and nanocarbon blackes (NCBs) obtained in this work met satisfactory experimental demands for study of cellular uptake and toxicity. The experiments showed that the labeling process was based on physical adsorption of low valent technetium resulted from reduction reaction on the surface of the carbon nanomaterials.

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碳纳米颗粒的放射性99mTc标记

99mTc Labeling of Carbon Nanomaterials

碳纳米颗粒的放射性^99mTc标记

^99mTc Labeling of Carbon Nanomaterials