Abstract: Within the framework of Lanzhou quantum molecular dynamics(LQMD) transport model, the isospin and in-medium effects on the hyperon production and kinetic energy spectra in the reaction of different heavy-ion reaction are investigated thoroughly. A repulsive hyperon-nucleon potential which is related to the hyperon momentum and baryon density from the chiral effective field theory is implemented into the model. The correction on threshold energy of the elementary hyperon cross section is taken into account. It is found that the \varSigma yields are suppressed in the domain of midrapidity and domain of kinetic energy spectra with the potential. The emission behavior of the hyperons is also affected by the repulsive hyperon-nucleon potential. The hyperons tend to move along the direction of the beam and along the direction perpendicular to the reaction plane. Finally, we found that \varSigma^-/\varSigma^+ yield ratio depends on the stiffness of nuclear symmetry energy in the high-energy region. The \varSigma^-/\varSigma^+ yield ratio with a hard symmetry energy is increased by the repulsive hyperon-nucleon potential. And it is found that the compressibility of nuclear matter will affect the hyperon production obviously.