Abstract: Based on the influence "hydrogen bubbles" and "helium bubbles", which are produced by the neutron induced reactions on Fe, of the new nuclear energy utilization system, the ^56,54Fe(n, α)^53,51Cr, ^56,54Fe(n, p)^56,54Mn cross sections are calculated in this work. The physical model (including energy level density, Correction, nuclear temperature, optical potential parameters, etc.) parameters were adjusted according to the existing experimental data and evaluation data of ^56,54Fe(n, α)^53,51Cr, ^56,54Fe(n, p)^56,54Mn cross sections, and a set of universal parameters were obtained. Based on the adjusted parameters, the TALYS program is used for calculating ^56,54Fe(n, α)^53,51Cr, ^56,54Fe(n, p)^56,54Mn reaction datas, including energy differential cross section and double differential cross section. Furthermore, the results are all in good agreement with the experimental data and evaluation data in the region of incident neutron energy from 0 to 175 MeV. By obtaining the universal parameters, new method was added to our nuclear reaction theory and laid the foundation for the nuclear data evaluation.