Abstract: The atmospheric cosmogenic nuclides of ¹⁰Be, ⁷Be, ²²Na are of great significance to research on global climate change and atmospheric environmental governance, as the sensitivity tracer of the Stratosphere-Troposphere Exchange(STE) dynamic processes. The current status of the international research on the application of these nuclides in STE and the difficulties are introduced. The advantages and research basis of Accelerator Mass Spectrometry(AMS) in this respect are summarized. Feasibility analysis and exploration of the key technologies faced by AMS measurement of ⁷Be and ²²Na are presented based on the compact low energy AMS system and the established ¹⁰Be measurement method of Tianjin University.