Abstract: The irradiation hardening and embrittlement behavior of three kinds of Oxide Dispersion Strengthened(ODS) steel (MA956, 16Cr-4Al, 16Cr-0.1Ti) are investigated by using the HIRFL(Heavy Ion Research Facility in Lanzhou). The main motivation is to find the relation between diameter and density of the oxides and irradiation hardening/embrittlement behavior of different ODS steels. These three kind of materials are irradiated by Ne and Ni ions, and get a uniform damage layer by using the energy degrader. The Nano-hardness and elongation of the materials are obtained by Nano-indentation and small punch test. The sink strength was calculated with the mean diameter and density of the materials. Then followed by nano-indentation test and small punch test to get the irradiation hardening and ductility loss. Results show that irradiation resistance of the materials rise with sink strength(S) increasing.