Abstract: Silicon Photomultiplier (SiPM) is a new generation of semiconductor photon detector, which is widely used in high-energy physics, nuclear medical imaging and nuclear physics and other fields. As the bias voltage of different SiPM is different, a high voltage power supply with adjustable voltage and temperature adaptive function is designed to meet the working voltage demand of SiPM. High voltage power supply mainly uses DC/DC module to generate high voltage to supply power to SiPM.The voltage of the high-voltage power supply can reach up to 200 V. The DC/DC module outputs different voltage values by changing the resistance value of the potentiometer to carry out partial voltage. Finally, the stability of DC/DC module, temperature adaptive testing, the performance and working characteristics of the high-voltage power supply plate were completed. The results show that the integral nonlinearity of the DC/DC module is 0.14‰, and the module works steadily. At different temperatures, the maximum change rate of system gain is 1.12%, and the system gain remains relatively stable. The maximum fluctuation of the self-made high-voltage power supply is about 0.01 V, and the work is stable. The ripple coefficient is below 0.02%, with low ripple. Meanwhile, in the same test environment, the resolution of the all-purpose peak of the high-voltage power supply and the commercial power supply are 7.84% and 9.88% respectively, and the performance of the self-made high-voltage power supply is better than that of the commercial power supply.