Abstract: We study the large transverse momentum dilepton produced by the photon-nucleon interactions in the peripheral Au-Au collisions at RHIC and Pb-Pb collisions at LHC. We calculate the dilepton production yield by using the perturbative QCD factorization approach and the Weizsäcker-Williams approximation. The numerical results indicate that the photon-nucleon collision processes is negligible by comparing with the conventional large transverse momentum dilepton production at RHIC energies. However, in the large transverse momentum region, the photon-nucleon collision could be an important large transverse momentum dilepton source in the peripheral heavy ion collisions at LHC.