Abstract: In antisymmetrized molecular dynamics(AMD) model, the binding energies and root mean square (RMS) radii of ⁴He, ⁶Li, ¹²C, ²⁰Ne, ⁴⁰Ca and ⁶⁰Ni in their own mean field were studied by three sets of Gogny interactions (g0, g0as and g0ass). The binding energies of isotopes with atomic numbers from 1 to 18 were studied systematically. Comparing with the experimental data, it is found that the result of g0 is the best. These investigations would provide clues to the study of the nuclear reaction mechanism such as fusion in low energy region and multi fragmentation in medium energy region by AMD.