碳离子治疗中分野照射技术的Monte Carlo模拟
Monte Carlo Simulation of Field Patching Technique in Carbon Ion Beam Therapy
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摘要: 为阐述分野照射治疗方式应用于中国科学院近代物理研究所(IMP) 肿瘤重离子临床治疗试验研究的理论基础，利用Monte Carlo (MC) 软件包Gate/Geant4 模拟计算了碳离子束分野照射分衔接处的横向剂量分布，得到了患者摆位误差±1.0 mm范围内的横向剂量分布和分野衔接处中心剂量随分野间距的变化关系，计算了分野间距5.0 mm的横向剂量分布。将分野间距5.0 mm的分野照射与整野照射的MC结果进行比较，发现：在靶区范围内两者模拟的剂量偏差在6.8% 以内，符合程度较好，并提出了在患者定位精确度较高的情况下(即患者治疗体位摆位误差在±1.0 mm范围) 解决分野衔接处剂量热点问题的可行方法，从而较大幅度地提高了分野照射时靶区范围内的剂量均匀性。To characterize the theoretical basis of eld patching technique in carbon ion beam therapy, Monte Carlo software package Gate/Geant4 was used to simulate the lateral dose distribution of matched elds. The lateral dose distribution of the matched elds within 1.0 millimeter of patient positioning error and the relationship between the central dose of the matched elds and the eld patching gap were obtained. Moreover, the lateral dose pro le of eld patching irradiation with 5.0 mm gap was simulated. While comparing the lateral dose distribution of eld patching irradiation with 5.0 mm gap with the undivided eld irradiation, a good agreement between both results with a maximum dose deviation of 6.8% was observed within the target volume.Hence a feasible method for solving the issue of dose hotspots during eld patching under the condition of higher patient positioning accuracies (patient positioning error within 1.0 millimeter) was proposed and the dose homogeneit within the target volume could be greatly improved when eld patching technique is adopted in carbon ion beam therapy.Abstract: To characterize the theoretical basis of eld patching technique in carbon ion beam therapy, Monte Carlo software package Gate/Geant4 was used to simulate the lateral dose distribution of matched elds. The lateral dose distribution of the matched elds within 1.0 millimeter of patient positioning error and the relationship between the central dose of the matched elds and the eld patching gap were obtained. Moreover, the lateral dose pro le of eld patching irradiation with 5.0 mm gap was simulated. While comparing the lateral dose distribution of eld patching irradiation with 5.0 mm gap with the undivided eld irradiation, a good agreement between both results with a maximum dose deviation of 6.8% was observed within the target volume.Hence a feasible method for solving the issue of dose hotspots during eld patching under the condition of higher patient positioning accuracies (patient positioning error within 1.0 millimeter) was proposed and the dose homogeneit within the target volume could be greatly improved when eld patching technique is adopted in carbon ion beam therapy.
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