酵母β-葡聚糖对C离子辐射损伤小鼠免疫系统的防护作用
Protective Effect of Yeast β-glucan on Immune System of Mice Irradiated by Carbon Ions
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摘要: 用12C6+离子束对小鼠进行一次性全身辐照， 检测不同剂量的酵母β-葡聚糖对12C6+辐射损伤小鼠免疫系统的防护作用。 辐照后观察小鼠的体重、 毛色及行为变化， 照后第2天和第7天检测小鼠外周血中白细胞含量， 照后第8天检测小鼠胸腺和脾脏内SOD， GSHPX活性和MDA含量。 实验结果表明， 给予酵母β葡聚糖能减缓辐照引起的小鼠体重急剧下降， 增加小鼠外周血中白细胞含量，不同程度地恢复胸腺和脾脏SOD和GSHPX活性， 降低胸腺和脾脏MDA含量。 表明酵母β-葡聚糖对12C6+引起的小鼠辐射损伤具有防护作用。 To detect Yeast β-glucan’s protective effect on mice’s immune system after C ion beam radiation， mice were used as the test model. We observed the weight， hair color and behavior of mice everyday within a 7 d period of time after irradiation. Meanwhile， the content of white blood cell， on the 2nd and 7th day after irradiation was detected. We detected the thymus and spleen SOD， GSHPX activity and MDA content of the mice on the 8th day. The results showed that yeast βglucan could reduce the rapid weight loss of mice， increase white blood cell content， increase thymus and spleen SOD， GSHPX activity， decrease MDA content of thymus and spleen. These results indicate that yeast βglucan can protect mice’s immune system against C ion beam radiation damage.
Abstract: To detect Yeast β-glucan’s protective effect on mice’s immune system after C ion beam radiation， mice were used as the test model. We observed the weight， hair color and behavior of mice everyday within a 7 d period of time after irradiation. Meanwhile， the content of white blood cell， on the 2nd and 7th day after irradiation was detected. We detected the thymus and spleen SOD， GSHPX activity and MDA content of the mice on the 8th day. The results showed that yeast βglucan could reduce the rapid weight loss of mice， increase white blood cell content， increase thymus and spleen SOD， GSHPX activity， decrease MDA content of thymus and spleen. These results indicate that yeast βglucan can protect mice’s immune system against C ion beam radiation damage.
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