基于飞行时间技术的PET发展历史与现状

贠明凯; 李婷; 章志明; 张玉包; 单保慈; 魏龙

doi:10.11804/NuclPhysRev.29.02.162

基于飞行时间技术的PET发展历史与现状

History and Current Status of PET Devolopment based on Time of Flight

摘要

摘要: 简要介绍了基于飞行时间（Time of Flight，简称TOF）技术的正电子发射断层扫描成像（Positron Emission Tomography，简称PET）的基本原理，回顾了TOF-PET成像设备的发展历史，讨论了影响TOFPET时间分辨率的主要因素，并对TOF-PET给图像重建技术带来的挑战进行了分析。最后，重点介绍了TOF-PET技术所带来的优势，使用TOF技术可以有效地改善图像质量，并且为临床诊断和临床前研究带来便利。 The principle of time of flight (TOF) positron emission tomography (PET) and a brief review of the history of TOF-PET are introduced. The factors influencing the time resolution of a TOF-PET scanner are presented， especially focus on the intrinsic properties of scintillators and frontend electronics. Challenges and achievements of the structure of data organization and image reconstruction are reviewed. Finally， the benefits of TOF-PET on image quality improvement and tumor detection are emphasized.

Abstract: The principle of time of flight (TOF) positron emission tomography (PET) and a brief review of the history of TOF-PET are introduced. The factors influencing the time resolution of a TOF-PET scanner are presented， especially focus on the intrinsic properties of scintillators and frontend electronics. Challenges and achievements of the structure of data organization and image reconstruction are reviewed. Finally， the benefits of TOF-PET on image quality improvement and tumor detection are emphasized.
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