p73变异体研究现状及其在肿瘤放疗中的应用前景

Progress on p73 Variant and Its Possible Application in Tumor Radiotherapy

摘要: p73基因是p53抑癌基因家族的新成员。 p73有两组蛋白异构体: TAp73和DNp73。 TAp73具有诱导细胞周期停滞和细胞凋亡的能力，而DNp73却有与之相反的能力，具有肿瘤促进作用。对p73基因两面性的特点及研究进展作一综述。最后结合重离子治疗肿瘤，探讨了p73联合重离子治疗的新思路。 p73 was the first identified homologue of the tumor suppressor gene, p53. p73 has two groups of protein isoforms: TAp73 and DNp73. TAp73 can induce cell cycle arrest, resulting in the ability of apoptosis, however DNp73 has antagonistic property of a tumor promoting effect. In this paper, the dual roles of p73 gene and its research progress was reviewed. Finally, combined with heavy ion treatment of tumor, we explored some new ideas of p73heavy ion joint therapy.

Abstract: p73 was the first identified homologue of the tumor suppressor gene, p53. p73 has two groups of protein isoforms: TAp73 and DNp73. TAp73 can induce cell cycle arrest, resulting in the ability of apoptosis, however DNp73 has antagonistic property of a tumor promoting effect. In this paper, the dual roles of p73 gene and its research progress was reviewed. Finally, combined with heavy ion treatment of tumor, we explored some new ideas of p73heavy ion joint therapy.