小肠电离辐射损伤研究进展

Advances in Small Intestinal Ionizing Radiation Injury Research

摘要: 肠道的电离辐射损伤是腹部及盆腔肿瘤放射治疗过程中的剂量限制因素。综述了小肠电离辐射损伤的临床症状、小肠上皮及粘膜下层基质改变、信号分子表达变化、组织学变化和超微结构变化。简介了中国科学院近代物理研究所重离子束辐射生物医学重点实验室正在进行的有关小肠重离子辐射损伤及防护方面的研究工作。
Intestinal ionising radiation injuries are a dose limiting factor in the course of radiotherapy of abdominal and pelvic malignancies. In this paper it is reviewed that ionizing radiation injuries of small intestine, including clinical symptoms, epithelium and submucosa changes, signal molecular expression changes, histological and ultrastructure changes. The ongoing works of our laboratory on subjects of intestinal injuries induced by heavy ions and protection against these injuries are also presented.

Abstract: Intestinal ionising radiation injuries are a dose limiting factor in the course of radiotherapy of abdominal and pelvic malignancies. In this paper it is reviewed that ionizing radiation injuries of small intestine, including clinical symptoms, epithelium and submucosa changes, signal molecular expression changes, histological and ultrastructure changes. The ongoing works of our laboratory on subjects of intestinal injuries induced by heavy ions and protection against these injuries are also presented.