Survivin表达在高LET射线诱导细胞凋亡中

金晓东; 李强; 吴庆丰; 李萍; 陶家军; 巩莉; 戴中颍; 刘新国

doi:10.11804/NuclPhysRev.27.02.202

Survivin表达在高LET射线诱导细胞凋亡中

A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

摘要

摘要: 先前的研究表明，肿瘤细胞中survivin的高表达与细胞对高传能线密度(LET)射线的辐射抗性相关。研究了survivin表达在高LET射线诱导的细胞凋亡中的作用，发现抑制survivin表达对高LET C离子辐射诱导的Bcl-2和Bax表达没有明显的影响。在高LET射线辐照中， survivin可能通过抑制caspase-3和-9活性的途径，抑制了细胞凋亡。It has been proven that overexpression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study， action mechanisms of survivin gene in apoptosis induced by highLET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.

Abstract: It has been proven that over expression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study，action mechanisms of survivin gene in apoptosis induced by high LET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.

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