MicroRNA发现的研究现状及重离子辐照相关应用前景

Progress on Finding Novel MicroRNAs and Expectation of Heavy Ion Irradiation Application in This Field

摘要: MicroRNA(miRNA)是一类大小为19—24个核苷酸的非编码RNA，它们通过与靶基因的信使RNA(mRNA)结合在转录后水平调节靶基因的表达，因而在广泛的生物学过程中发挥重要作用。首先从miRNA的获得和鉴定两方面对目前miRNA发现工作进行了概括，然后分析和总结了近年来人源miRNA发现工作的现状，最后提出有关新miRNA发现工作的新想法。 MicroRNAs(miRNAs) are one kind of small noncoding RNAs of 19—24 nucleotides that transcriptionally regulate the expression of target genes by binding to their mRNA and thus play a central role in gene regulation in a wide arrange of biological processes. In this paper， we reviewed the clone and identification of novel miRNAs， summarized recent work on novel human miRNA recognization， and proposed a potentially feasible way to discover more human miRNAs.

Abstract: MicroRNAs(miRNAs) are one kind of small noncoding RNAs of 19—24 nucleotides that transcriptionally regulate the expression of target genes by binding to their mRNA and thus play a central role in gene regulation in a wide arrange of biological processes. In this paper， we reviewed the clone and identification of novel miRNAs， summarized recent work on novel human miRNA recognization， and proposed a potentially feasible way to discover more human miRNAs.