MAPK途径与细胞的辐射应

MAPK Pathways in Radiation Responses of Cells

摘要: MAPK信号转导途径在细胞辐射应答中起着重要作用， ERK, JNK, P38 MAPK和大 MAPK 4条不同的 MAPK通路在受辐射细胞中扮演着不同角色，它们的协调控制作用决定着细胞受辐照后的命运。描述了辐射应答中的这4条不同的 MAPK途径，并讨论了这些途径在辐射应答中的作用。MAPK signal transduction pathways play crucial roles in the radiation responses of cells. Four MAPK pathways， ERK， JNK， P38 MAPK and big MAPK pathway induce different effects in the radiation exposed cells. Their corresponding regulations foreordain the cells after exposure. This review describes these four MAPK pathways in radiation responses and discusses their functions in radiation responses respectively.

Abstract: MAPK signal transduction pathways play crucial roles in the radiation responses of cells. Four MAPK pathways， ERK， JNK， P38 MAPK and big MAPK pathway induce different effects in the radiation exposed cells. Their corresponding regulations foreordain the cells after exposure. This review describes these four MAPK pathways in radiation responses and discusses their functions in radiation responses respectively.