带电粒子致细胞失活的理论模型(英文)

Theoretical Models of Cell Inactivation by Ionizing Particles

摘要: 介绍了经辐射损伤后细胞失活或存活的理论模型及相关问题的一些研究工作。重点考虑了径迹结构和能量沉积特点的新的细胞失活模型。在径迹结构模拟的基础上, 计算并分析了DNA损伤谱, 同时把径迹结构得到的损伤谱与细胞存活联系起来, 初步在分子水平上理解了细胞失活或存活的机制。The several theoretical models of cell inactivation or cell survival fraction are introduced. Emphasis is placed on a new model——Ionization Ionization Clustering Cluster model. In order to understand some of the mechanisms of DNA damage related to cell killing and their dependence on radiation quality, the yields of single track lethal events are compared with the estimated yields of different classes of complex DNA lesions calculated by a fast Monte Carlo methods.

Abstract: The several theoretical models of cell inactivation or cell survival fraction are introduced. Emphasis is placed on a new model——Ionization Ionization Clustering Cluster model. In order to understand some of the mechanisms of DNA damage related to cell killing and their dependence on radiation quality, the yields of single track lethal events are compared with the estimated yields of different classes of complex DNA lesions calculated by a fast Monte Carlo methods.