低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应

Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γray to hep G2 Cells

摘要: 以低剂量γ射线(0.05 Gy)预照射人肝癌细胞hep G2， 8 h后再用高剂量(3 Gy)照射，测定了细胞的克隆存活率和细胞周期。结果表明，低剂量辐射预处理可诱导hep G2细胞产生克隆存活适应性反应，并且有助于细胞通过G2/M期阻滞；低剂量辐射诱导的克隆存活适应性反应与增强的通过细胞周期阻滞的能力之间有一定的相关性。
Human hepatoma cells hep G2 were irradiated with 3 Gy of γray 8 hours after primed with 0.05 Gy of γray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by preirradiation with low dose of γray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest.

Abstract: Human hepatoma cells hep G2 were irradiated with 3 Gy of γray 8 hours after primed with 0.05 Gy of γray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by preirradiation with low dose of γray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest.