Abstract: Positron Emission Computed Tomography(PET) is an advanced nuclear medical imaging technology, and the brain PET is a dedicated device used for brain imaging. In a brain PET imaging system, the front-end electronics is one of the important parts, which is responsible for high-precision charge and time measurement of the signal generated by the detector. Based on the application specific integrated circuit(ASIC) developed by University of Science and Technology of China, this paper presents the design of brain PET front-end prototype electronics, and the digital summation method and time-to-digital converter(TDC) for charge and time measurement. The charge accuracy and time accuracy of this electronics have been tested in the laboratory environment. The test results show that the charge accuracy is better than 3‰ FWHM(Full Width at Half Maximum), and the time accuracy is better than 60 ps RMS.