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Article Navigation >  Nuclear Physics Review  > 2014  >  31(3): 423-427

JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and 12C6+[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423
Citation: JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and 12C6+[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423
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Radioprotective Effects of GANRA-5 to X-rays and 12C6+

doi: 10.11804/NuclPhysRev.31.03.423

  • Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics,Mianyang 621900, Sichuan, China;

  • Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2014-09-20
  • The radio-protective effects on human embryonic lung fibroblast MRC-5 of an oxazolone derivative named GANRA-5 were studied. MTT test was used to evaluate the toxicity and H2AX foci assay was used to test the influence of GANRA-5 on the DSB (double-stranded break) formation after irradiation. It is found that GANRA-5 exhibited low toxicity and high radio-protective effects on MRC-5 cells against both X-ray and 12C6+ ion beam. It is also found that it can act as a scavenger of free radicals. These results suggest that GANRA-5 is a promising radioprotectant.
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Radioprotective Effects of GANRA-5 to X-rays and 12C6+

doi: 10.11804/NuclPhysRev.31.03.423
  • Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics,Mianyang 621900, Sichuan, China;
  • Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2014-09-20

Abstract: The radio-protective effects on human embryonic lung fibroblast MRC-5 of an oxazolone derivative named GANRA-5 were studied. MTT test was used to evaluate the toxicity and H2AX foci assay was used to test the influence of GANRA-5 on the DSB (double-stranded break) formation after irradiation. It is found that GANRA-5 exhibited low toxicity and high radio-protective effects on MRC-5 cells against both X-ray and 12C6+ ion beam. It is also found that it can act as a scavenger of free radicals. These results suggest that GANRA-5 is a promising radioprotectant.

JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and 12C6+[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423
Citation: JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and 12C6+[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423
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