Functions of PML in Responding to Ionizing Radiation

YAO Bin; PEI Hailong; GAO Xiaofei; WANG Jufang; ZHOU Guangming

doi:10.11804/NuclPhysRev.30.02.190

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YAO Bin, PEI Hailong, GAO Xiaofei, WANG Jufang, ZHOU Guangming. Functions of PML in Responding to Ionizing Radiation[J]. Nuclear Physics Review, 2013, 30(2): 190-194. doi: 10.11804/NuclPhysRev.30.02.190

Citation:

YAO Bin, PEI Hailong, GAO Xiaofei, WANG Jufang, ZHOU Guangming. Functions of PML in Responding to Ionizing Radiation[J]. Nuclear Physics Review, 2013, 30(2): 190-194. doi: 10.11804/NuclPhysRev.30.02.190

Functions of PML in Responding to Ionizing Radiation

doi: 10.11804/NuclPhysRev.30.02.190

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2013-06-20

Abstract

Promyelocytic leukemia (PML) plays an important role in natural immune, angiogenesis, and transcriptional regulation. It also participates in apoptosis and other radiobiological effects. We confirm that the PML expression in G1 and S phase cells is relatively higher than that in M and G2 phase cells. We also demonstrate that the expression of PML protein is up-regulated in both dose- and time-dependent manner after cells are exposed to ionizing radiation. The size and amount of PML-nuclear bodies (PML-NBs) increase in a dose-dependent manner whereas the fluorescence intensity of PML-NBs decreases. Taken together, PML is sensitive to ionizing radiation and its functional studies are facilitated to reveal the mechanisms underlying radiobiological effects.
- PML,
- PML-NBs,
- ionizing radiation,
- radiotherapy,
- biological effect,
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Functions of PML in Responding to Ionizing Radiation

doi: 10.11804/NuclPhysRev.30.02.190

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2013-06-20

Key words:

Abstract: Promyelocytic leukemia (PML) plays an important role in natural immune, angiogenesis, and transcriptional regulation. It also participates in apoptosis and other radiobiological effects. We confirm that the PML expression in G1 and S phase cells is relatively higher than that in M and G2 phase cells. We also demonstrate that the expression of PML protein is up-regulated in both dose- and time-dependent manner after cells are exposed to ionizing radiation. The size and amount of PML-nuclear bodies (PML-NBs) increase in a dose-dependent manner whereas the fluorescence intensity of PML-NBs decreases. Taken together, PML is sensitive to ionizing radiation and its functional studies are facilitated to reveal the mechanisms underlying radiobiological effects.

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