Advanced Search
Volume 30 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Nuclear Physics Review  > 2013  >  30(1): 79-83

XU Shuai, ZHANG Hong, LIU Yang, MA Xiao-fei. Protective Effect of Diallyl Disulfide against the Irradiation Damage in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2013, 30(1): 79-83. doi: 10.11804/NuclPhysRev.30.01.079
Citation: XU Shuai, ZHANG Hong, LIU Yang, MA Xiao-fei. Protective Effect of Diallyl Disulfide against the Irradiation Damage in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2013, 30(1): 79-83. doi: 10.11804/NuclPhysRev.30.01.079
shu

Protective Effect of Diallyl Disulfide against the Irradiation Damage in Mice Induced by 12C6+ Ion Beams

doi: 10.11804/NuclPhysRev.30.01.079

  • Institute of Modern Physics , Chinese Academy of Sciences,Lanzhou 730000,China;

  • Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000,China;

  • Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province,Lanzhou 730000,China;

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2013-03-20
  • The radioprotective effect of Diallyl disulfide (DADS) on 12C6+ ion irradiation was studied. Pretreated with DADS of different concentration, male Kung-Ming mice were exposed to whole body irradiation with dosage of 4 Gy 12C6+ ion. The animals were sacrificed after irradiation. Then the bone marrow cells micronucleus rate, malondialdehyde (MDA) levels, content of protein carbonylation, total antioxidant capacity ( T-AOC) and alanine aminotransferase ( ALT ) activity were measured. As compared with those in irradiated group, the ratio of micronucleus cells in marrow and the hepatic ALT activity in the pretreatment group with low dose DADS decreased significantly ( p < 0.001 ). Similarly,the content of protein carbonylation and the levels of MDA droped dramatically in the group with middle dose DADS treatment ( p < 0.05 ). On the contrary, the hepatic T-AOC increased markedly in the group of pretreatment with low dose DADS ( p < 0.05 ). The results showed that DADS protect lipoid, protein and genetic material from 12C6+ ion irradiation by right of resisting oxidative stress.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2004) PDF downloads(480) Cited by()

Proportional views

Protective Effect of Diallyl Disulfide against the Irradiation Damage in Mice Induced by 12C6+ Ion Beams

doi: 10.11804/NuclPhysRev.30.01.079
  • Institute of Modern Physics , Chinese Academy of Sciences,Lanzhou 730000,China;
  • Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000,China;
  • Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province,Lanzhou 730000,China;
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2013-03-20

Abstract: The radioprotective effect of Diallyl disulfide (DADS) on 12C6+ ion irradiation was studied. Pretreated with DADS of different concentration, male Kung-Ming mice were exposed to whole body irradiation with dosage of 4 Gy 12C6+ ion. The animals were sacrificed after irradiation. Then the bone marrow cells micronucleus rate, malondialdehyde (MDA) levels, content of protein carbonylation, total antioxidant capacity ( T-AOC) and alanine aminotransferase ( ALT ) activity were measured. As compared with those in irradiated group, the ratio of micronucleus cells in marrow and the hepatic ALT activity in the pretreatment group with low dose DADS decreased significantly ( p < 0.001 ). Similarly,the content of protein carbonylation and the levels of MDA droped dramatically in the group with middle dose DADS treatment ( p < 0.05 ). On the contrary, the hepatic T-AOC increased markedly in the group of pretreatment with low dose DADS ( p < 0.05 ). The results showed that DADS protect lipoid, protein and genetic material from 12C6+ ion irradiation by right of resisting oxidative stress.

XU Shuai, ZHANG Hong, LIU Yang, MA Xiao-fei. Protective Effect of Diallyl Disulfide against the Irradiation Damage in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2013, 30(1): 79-83. doi: 10.11804/NuclPhysRev.30.01.079
Citation: XU Shuai, ZHANG Hong, LIU Yang, MA Xiao-fei. Protective Effect of Diallyl Disulfide against the Irradiation Damage in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2013, 30(1): 79-83. doi: 10.11804/NuclPhysRev.30.01.079
shu

    HTML

Catalog

    Copyright by 《Nuclear Physics Review》Editorial Office

    Address: 509 Nanchang Road, LanzhouPostCode: 730000Tel: 0931-4969374, 4969371Fax: 0931-8272100E-mail:npr@impcas.ac.cn

    陇ICP备2023003351号-2 甘公网安备 62010202000723号

    Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return