Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations

ZHOU Xin; WANG Zhen-hua; ZHANG Hong

doi:10.11804/NuclPhysRev.29.04.399

PDF
Cite
Share
facebook

twitter

google

linkedin

Volume 29 Issue 4

Turn off MathJax

Article Contents

Article Navigation > Nuclear Physics Review > 2012 > 29(4): 399-405

ZHOU Xin, WANG Zhen-hua, ZHANG Hong. Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations[J]. Nuclear Physics Review, 2012, 29(4): 399-405. doi: 10.11804/NuclPhysRev.29.04.399

Citation:

ZHOU Xin, WANG Zhen-hua, ZHANG Hong. Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations[J]. Nuclear Physics Review, 2012, 29(4): 399-405. doi: 10.11804/NuclPhysRev.29.04.399

Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations

doi: 10.11804/NuclPhysRev.29.04.399

1.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2.Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; 3.Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China; 4.Graduate University of China Academy of Sciences, Beijing 100049, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2012-12-20

Abstract

Current advance in ionizing radiationinduced mitochondrial DNA damage and mutations is reviewed， in addition with the essential differences between mtDNA and nDNA damage and mutations. To extent the knowledge about radiation induced mitochondrial alterations， the researchers in Institute of Modern Physics， Chinese Academy of Sciences developed some technics such as realtime PCR， longPCR for accurate quantification of radiation induced damage and mutations， and indepth investigation about the functional changes of mitochondria based on mtDNA damage and mutations were also carried out. In conclusion， the important role of mitochondrial study in radiation biology is underlined， and further study on mitochondrial study associated with late effect and metabolism changes in radiation biology is pointed out.

- mitochondrial DNA,
- ionizing radiation
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(1798) PDF downloads(750) Cited by()

Proportional views

Current Study on Ionizing Radiationinduced Mitochondial DNA Damage and Mutations

doi: 10.11804/NuclPhysRev.29.04.399

1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2.Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; 3.Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China; 4.Graduate University of China Academy of Sciences, Beijing 100049, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2012-12-20

Key words:

mitochondrial DNA /
ionizing radiation

Abstract: Current advance in ionizing radiationinduced mitochondrial DNA damage and mutations is reviewed， in addition with the essential differences between mtDNA and nDNA damage and mutations. To extent the knowledge about radiation induced mitochondrial alterations， the researchers in Institute of Modern Physics， Chinese Academy of Sciences developed some technics such as realtime PCR， longPCR for accurate quantification of radiation induced damage and mutations， and indepth investigation about the functional changes of mitochondria based on mtDNA damage and mutations were also carried out. In conclusion， the important role of mitochondrial study in radiation biology is underlined， and further study on mitochondrial study associated with late effect and metabolism changes in radiation biology is pointed out.


Citation: