Study on Radioprotective Effects of GANRAlike Medicine

ZHU Ming-yue; PEI Hai-long; YE Wen-ling; ZHANG Ya-nan; DING Nan; WANG Ju-fang; LI Wen-jian; ZHOU Guang-ming

doi:10.11804/NuclPhysRev.29.01.109

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Article Navigation > Nuclear Physics Review > 2012 > 29(1): 109-113

ZHU Ming-yue, PEI Hai-long, YE Wen-ling, ZHANG Ya-nan, DING Nan, WANG Ju-fang, LI Wen-jian, ZHOU Guang-ming. Study on Radioprotective Effects of GANRAlike Medicine[J]. Nuclear Physics Review, 2012, 29(1): 109-113. doi: 10.11804/NuclPhysRev.29.01.109

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ZHU Ming-yue, PEI Hai-long, YE Wen-ling, ZHANG Ya-nan, DING Nan, WANG Ju-fang, LI Wen-jian, ZHOU Guang-ming. Study on Radioprotective Effects of GANRAlike Medicine[J]. Nuclear Physics Review, 2012, 29(1): 109-113. doi: 10.11804/NuclPhysRev.29.01.109

Study on Radioprotective Effects of GANRAlike Medicine

doi: 10.11804/NuclPhysRev.29.01.109

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2012-03-20

Abstract

After three days of medicine administrated, Kunming mice were exposured to 8 Gy of 100 kVp Xrays. Hemogram, viscere, survival, MDA yields and SOD activity were examined. Results showes that, (1) Survival of medicineadministrated mice were similar to the control group. After irradiation, survival dropped significantly. It took 20 days for the control group to reach to 50% survival, while 9 days for DMSO group 29 days for 1# drug group, and 24 days for 5# drug group. (2) The medicine per se had no obvious impacts on visceral indexes. Liver index and spleen index of the control group and DMSO group were elevated after irradiated, while those of medicineadministrated group did not change much. (3) The groups treated by DMSO and 1# drug had high yield of MDA, but low activity of SOD. Compared with DMSO group, 5# drug had high SOD activity while low MDA level. Irradiation increased MDA level but decreased SOD activity of every group, However, 5# drug still showed higher SOD activity and lower MDA level than DMSO group. (4) The medicine did not show distinctive contributions to variation of hemogram. In summary, our results demonstrated that GANRAlike 1# and 5# medicine had radioprotective effects and their mechanisms might be related to the scavenging ability of free radicals.
- GANRA like medicine,
- radioprotective,
- animal model
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Study on Radioprotective Effects of GANRAlike Medicine

doi: 10.11804/NuclPhysRev.29.01.109

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2012-03-20

Key words:

Abstract: After three days of medicine administrated, Kunming mice were exposured to 8 Gy of 100 kVp Xrays. Hemogram, viscere, survival, MDA yields and SOD activity were examined. Results showes that, (1) Survival of medicineadministrated mice were similar to the control group. After irradiation, survival dropped significantly. It took 20 days for the control group to reach to 50% survival, while 9 days for DMSO group 29 days for 1# drug group, and 24 days for 5# drug group. (2) The medicine per se had no obvious impacts on visceral indexes. Liver index and spleen index of the control group and DMSO group were elevated after irradiated, while those of medicineadministrated group did not change much. (3) The groups treated by DMSO and 1# drug had high yield of MDA, but low activity of SOD. Compared with DMSO group, 5# drug had high SOD activity while low MDA level. Irradiation increased MDA level but decreased SOD activity of every group, However, 5# drug still showed higher SOD activity and lower MDA level than DMSO group. (4) The medicine did not show distinctive contributions to variation of hemogram. In summary, our results demonstrated that GANRAlike 1# and 5# medicine had radioprotective effects and their mechanisms might be related to the scavenging ability of free radicals.

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