Changes of  Immune  System  in  Mice Irradiated  by  Continual  X rays

XIE Yi; ZHANG  Hong; #; DANG  Bing-rong; HAO  Ji-fang; WANG Xiao-hu

doi:10.11804/NuclPhysRev.26.04.348

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Article Navigation > Nuclear Physics Review > 2009 > 26(4): 348-351

XIE Yi, ZHANG Hong, #, DANG Bing-rong, HAO Ji-fang, WANG Xiao-hu. Changes of Immune System in Mice Irradiated by Continual X rays[J]. Nuclear Physics Review, 2009, 26(4): 348-351. doi: 10.11804/NuclPhysRev.26.04.348

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XIE Yi, ZHANG Hong, #, DANG Bing-rong, HAO Ji-fang, WANG Xiao-hu. Changes of Immune System in Mice Irradiated by Continual X rays[J]. Nuclear Physics Review, 2009, 26(4): 348-351. doi: 10.11804/NuclPhysRev.26.04.348

Changes of Immune System in Mice Irradiated by Continual X rays

doi: 10.11804/NuclPhysRev.26.04.348

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2 Gansu Academy of Medical Sciences, Lanzhou 730050, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2009-12-20

Abstract

For estimating the effect of low doses Xray continual irradiation to immunity system of mouse， BALB/c mice were continually irradiated to 1.03 Gy by X rays at a dose rate of 0.2 Gy/min in 13 d. At 24 or 48 h after irradiation， the immunocyte cycle and apoptosis were determined by flow cytometry， and the thymus and spleen weights were measured too. The results showed that the cycle of thymocyte were arrested in G2/M at 24 h， the number of peripheral blood lymphocytes and thymocytes in G0/G1 phase at 48 h was up and the percentage of apoptosis had a significance increase in both of time points； the cycle of spleen lymphocytes was delayed in G0/G1 at 24 h， in S phase at 48 h， the apoptosis had a significance decrase at 24 and 48 h； spleen index declined significantly at 48 h. The results suggested that low doses continual Xray wholebody irradiation could activate different cell cycle checkpoints， and result in some changes of apoptosis and some damages to immunocytes. The continual Xray irradiation affects the organs differently， it might provide experiment basis for radioprotection.
- Xray continual irradiation,
- immunocyte,
- cellular cycle and apoptosis,
- thymus and spleen index,
- mouse
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Changes of Immune System in Mice Irradiated by Continual X rays

doi: 10.11804/NuclPhysRev.26.04.348

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2 Gansu Academy of Medical Sciences, Lanzhou 730050, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2009-12-20

Key words:

Abstract: For estimating the effect of low doses Xray continual irradiation to immunity system of mouse， BALB/c mice were continually irradiated to 1.03 Gy by X rays at a dose rate of 0.2 Gy/min in 13 d. At 24 or 48 h after irradiation， the immunocyte cycle and apoptosis were determined by flow cytometry， and the thymus and spleen weights were measured too. The results showed that the cycle of thymocyte were arrested in G2/M at 24 h， the number of peripheral blood lymphocytes and thymocytes in G0/G1 phase at 48 h was up and the percentage of apoptosis had a significance increase in both of time points； the cycle of spleen lymphocytes was delayed in G0/G1 at 24 h， in S phase at 48 h， the apoptosis had a significance decrase at 24 and 48 h； spleen index declined significantly at 48 h. The results suggested that low doses continual Xray wholebody irradiation could activate different cell cycle checkpoints， and result in some changes of apoptosis and some damages to immunocytes. The continual Xray irradiation affects the organs differently， it might provide experiment basis for radioprotection.

Citation: