Radiobiological Response of Cells Exposed to Radiations with Different LET

JING Xi-gang; LI Wen-jian; YANG Jian-she; WANG Zhuan-zi; WEI Wei

doi:10.11804/NuclPhysRev.26.03.259

PDF
Cite
Share
facebook

twitter

google

linkedin

Volume 26 Issue 3

Turn off MathJax

Article Contents

Article Navigation > Nuclear Physics Review > 2009 > 26(3): 259-262

JING Xi-gang, LI Wen-jian, YANG Jian-she, WANG Zhuan-zi, WEI Wei. Radiobiological Response of Cells Exposed to Radiations with Different LET[J]. Nuclear Physics Review, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259

Citation:

JING Xi-gang, LI Wen-jian, YANG Jian-she, WANG Zhuan-zi, WEI Wei. Radiobiological Response of Cells Exposed to Radiations with Different LET[J]. Nuclear Physics Review, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259

Radiobiological Response of Cells Exposed to Radiations with Different LET

doi: 10.11804/NuclPhysRev.26.03.259

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China;3 Life Science College, Northwest Normal University, Lanzhou 730070, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2009-09-20

Abstract

Human hepatoma SMMC7721 and normal liver L02 cells were irradiated with γrays，12C6+ and 36Ar18+ ion beams at the Heavy Ion Research Facility in Lanzhou(HIRFL). We reported the kinetic repair of chromosome breaks of L02 and SMMC7721 cells in 24 h of postirradiation time. The relative biological effectiveness(RBE) for inducing chromatid breaks were 3.6 for L02 and 3.5 for SMMC7721 cell lines at the linear energy transfer(LET) peak of 96.55 keV/μm 12C6+ ions， and 2.9 (both of the two cell lines) at 512 keV/μm 36Ar18+ ions.It suggested that the RBE of isochromatidtype breaks induced by 36Ar18+ was higher than those by 12C6+. We concluded that the high production of isochromatidtype breaks， induced by the densely ionizing track structure， could be regarded as a signature of high LET radiation exposure.
- heavy ion,
- linear energy transfer,
- prematurely chromosome condensation,
- relative biological effectiveness
References
Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views(3251) PDF downloads(712) Cited by()

Proportional views

Radiobiological Response of Cells Exposed to Radiations with Different LET

doi: 10.11804/NuclPhysRev.26.03.259

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China;3 Life Science College, Northwest Normal University, Lanzhou 730070, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2009-09-20

Key words:

Abstract: Human hepatoma SMMC7721 and normal liver L02 cells were irradiated with γrays，12C6+ and 36Ar18+ ion beams at the Heavy Ion Research Facility in Lanzhou(HIRFL). We reported the kinetic repair of chromosome breaks of L02 and SMMC7721 cells in 24 h of postirradiation time. The relative biological effectiveness(RBE) for inducing chromatid breaks were 3.6 for L02 and 3.5 for SMMC7721 cell lines at the linear energy transfer(LET) peak of 96.55 keV/μm 12C6+ ions， and 2.9 (both of the two cell lines) at 512 keV/μm 36Ar18+ ions.It suggested that the RBE of isochromatidtype breaks induced by 36Ar18+ was higher than those by 12C6+. We concluded that the high production of isochromatidtype breaks， induced by the densely ionizing track structure， could be regarded as a signature of high LET radiation exposure.

Citation: