Radiobiological Response of Cells Exposed to Radiations with Different LET
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Abstract
Human hepatoma SMMC7721 and normal liver L02 cells were irradiated with γrays，12C6+ and 36Ar18+ ion beams at the Heavy Ion Research Facility in Lanzhou(HIRFL). We reported the kinetic repair of chromosome breaks of L02 and SMMC7721 cells in 24 h of postirradiation time. The relative biological effectiveness(RBE) for inducing chromatid breaks were 3.6 for L02 and 3.5 for SMMC7721 cell lines at the linear energy transfer(LET) peak of 96.55 keV/μm 12C6+ ions， and 2.9 (both of the two cell lines) at 512 keV/μm 36Ar18+ ions.It suggested that the RBE of isochromatidtype breaks induced by 36Ar18+ was higher than those by 12C6+. We concluded that the high production of isochromatidtype breaks， induced by the densely ionizing track structure， could be regarded as a signature of high LET radiation exposure.
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