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YAN Shi-wei, ZHUO Yi-zhong. A Nonlinear Dynamical Model for Studying DNA Damage-induced p53-Mdm2 Interaction[J]. Nuclear Physics Review, 2006, 23(3): 315-321. doi: 10.11804/NuclPhysRev.23.03.315
Citation: YAN Shi-wei, ZHUO Yi-zhong. A Nonlinear Dynamical Model for Studying DNA Damage-induced p53-Mdm2 Interaction[J]. Nuclear Physics Review, 2006, 23(3): 315-321. doi: 10.11804/NuclPhysRev.23.03.315
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A Nonlinear Dynamical Model for Studying DNA Damage-induced p53-Mdm2 Interaction

doi: 10.11804/NuclPhysRev.23.03.315

  • Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, China ;2.Beijing Radiation Center, Beijing 100875, China ; 3.Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, China

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2006-09-20
  • Exploring the nonlinear dynamics of the negative feedback loop composed of p53 and Mdm2 proteins, we propose a signal-response model to study the dynamical mechanism of the different oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and population of cells. It is shown that the sustained and damped oscillatory dynamics could be described in a unified way when the dynamics of damage-derived signal is properly introduced.
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A Nonlinear Dynamical Model for Studying DNA Damage-induced p53-Mdm2 Interaction

doi: 10.11804/NuclPhysRev.23.03.315
  • Institute of Low Energy Nuclear Physics, Beijing Normal University, Beijing 100875, China ;2.Beijing Radiation Center, Beijing 100875, China ; 3.Center of Theoretical Nuclear Physics, National Laboratory of Heavy Ion Accelerator of Lanzhou, Lanzhou 730000, China
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2006-09-20

Abstract: Exploring the nonlinear dynamics of the negative feedback loop composed of p53 and Mdm2 proteins, we propose a signal-response model to study the dynamical mechanism of the different oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and population of cells. It is shown that the sustained and damped oscillatory dynamics could be described in a unified way when the dynamics of damage-derived signal is properly introduced.

YAN Shi-wei, ZHUO Yi-zhong. A Nonlinear Dynamical Model for Studying DNA Damage-induced p53-Mdm2 Interaction[J]. Nuclear Physics Review, 2006, 23(3): 315-321. doi: 10.11804/NuclPhysRev.23.03.315
Citation: YAN Shi-wei, ZHUO Yi-zhong. A Nonlinear Dynamical Model for Studying DNA Damage-induced p53-Mdm2 Interaction[J]. Nuclear Physics Review, 2006, 23(3): 315-321. doi: 10.11804/NuclPhysRev.23.03.315
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