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Article Navigation >  Nuclear Physics Review  > 2006  >  23(1): 43-45

WANG Zhuan-zi, LI Wen-jian, YANG Jian-she, ZHOU Li-bin, WEI Wei, MAO Shu-hong. Initial Damage of G2-chromosome in Hepatoma Cells Induced by γ-rays[J]. Nuclear Physics Review, 2006, 23(1): 43-45. doi: 10.11804/NuclPhysRev.23.01.043
Citation: WANG Zhuan-zi, LI Wen-jian, YANG Jian-she, ZHOU Li-bin, WEI Wei, MAO Shu-hong. Initial Damage of G2-chromosome in Hepatoma Cells Induced by γ-rays[J]. Nuclear Physics Review, 2006, 23(1): 43-45. doi: 10.11804/NuclPhysRev.23.01.043
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Initial Damage of G2-chromosome in Hepatoma Cells Induced by γ-rays

doi: 10.11804/NuclPhysRev.23.01.043

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2006-03-20
  • A chemically induced premature chromosome condensation technique with Calyculin-A has been employed to estimate the initial chromosome damage in HepG2 condensed in G2 phase and the percentage of aberrant cells after exposure to γ-rays. The results show that the dose-response for iso-chromatid breaks is linear-quadratic manner, while chromatid-type breaks and total chromatid breaks show a positive linear dose-response. The percent tages of all kinds of aberrant cells are increasing linearly with increasing doses. G2 chromatid-type breaks and the percentage of G2 chromatid-type aberrant cells are predominate in G2 total chromatid breaks induced b y γ-rays.
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Initial Damage of G2-chromosome in Hepatoma Cells Induced by γ-rays

doi: 10.11804/NuclPhysRev.23.01.043
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2006-03-20

Abstract: A chemically induced premature chromosome condensation technique with Calyculin-A has been employed to estimate the initial chromosome damage in HepG2 condensed in G2 phase and the percentage of aberrant cells after exposure to γ-rays. The results show that the dose-response for iso-chromatid breaks is linear-quadratic manner, while chromatid-type breaks and total chromatid breaks show a positive linear dose-response. The percent tages of all kinds of aberrant cells are increasing linearly with increasing doses. G2 chromatid-type breaks and the percentage of G2 chromatid-type aberrant cells are predominate in G2 total chromatid breaks induced b y γ-rays.

WANG Zhuan-zi, LI Wen-jian, YANG Jian-she, ZHOU Li-bin, WEI Wei, MAO Shu-hong. Initial Damage of G2-chromosome in Hepatoma Cells Induced by γ-rays[J]. Nuclear Physics Review, 2006, 23(1): 43-45. doi: 10.11804/NuclPhysRev.23.01.043
Citation: WANG Zhuan-zi, LI Wen-jian, YANG Jian-she, ZHOU Li-bin, WEI Wei, MAO Shu-hong. Initial Damage of G2-chromosome in Hepatoma Cells Induced by γ-rays[J]. Nuclear Physics Review, 2006, 23(1): 43-45. doi: 10.11804/NuclPhysRev.23.01.043
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