Abstract: According to the characteristics of deep burnup of fluorine salt cooled spherical bed high temperature reactor (FHR), the feasibility of transmutation of minor actinides by FHR is studied in this paper. The results show that: (1) the enrichment of U-235 is 19.75%, and the mass ratio of UO₂ to MAO₂ in triso is 18:1 after pebble optimized; (2) The flow rate of pebble in the core is 4.59 cm/d and the deepest burnup is 150 GWd/tHM; (3) The total transmutation rate of minor actinides is 26.16%. Among them, Np-237, Am-241 and Am-243 are transmuted by capture absorption and \beta decay to fission nuclide. Cm-243, Cm-244 and Cm-245 cannot transmute effectively, due to accumulation effect by capture adsorption and β decay.