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医用放射性同位素99Mo/99mTc生产现状和展望

李紫微 韩运成 王晓彧 张佳辰 王永峰 黄群英

李紫微, 韩运成, 王晓彧, 张佳辰, 王永峰, 黄群英. 医用放射性同位素99Mo/99mTc生产现状和展望[J]. 原子核物理评论, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
引用本文: 李紫微, 韩运成, 王晓彧, 张佳辰, 王永峰, 黄群英. 医用放射性同位素99Mo/99mTc生产现状和展望[J]. 原子核物理评论, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
LI Ziwei, HAN Yuncheng, WANG Xiaoyu, ZHANG Jiachen, WANG Yongfeng, HUANG Qunying. Production Status and Technical Prospects of Medical Radioisotope 99Mo/99mTc[J]. Nuclear Physics Review, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
Citation: LI Ziwei, HAN Yuncheng, WANG Xiaoyu, ZHANG Jiachen, WANG Yongfeng, HUANG Qunying. Production Status and Technical Prospects of Medical Radioisotope 99Mo/99mTc[J]. Nuclear Physics Review, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170

医用放射性同位素99Mo/99mTc生产现状和展望

doi: 10.11804/NuclPhysRev.36.02.170
基金项目: 国家自然科学基金项目(11605232);安徽省自然科学基金项目(1808085MA10)
详细信息
    作者简介:

    李紫微(1995-),女,河北保定人,在读研究生,从事医用放射性同位素研究;E-mail:ziwei.li@fds.org.cn

    通讯作者: 韩运成,E-mail:yuncheng.han@fds.org.cn
  • 中图分类号: TL92

Production Status and Technical Prospects of Medical Radioisotope 99Mo/99mTc

Funds: National Natural Science Foundation of China (11605232); Anhui Provincial Natural Science Foundation (1808085MA10)
  • 摘要: 99mTc是目前临床诊断应用最为广泛的医用放射性同位素。现有医用99mTc主要通过在实验堆中辐照高浓缩235U生成的99Mo衰变得到,存在工艺复杂、成本高、长距离运输损失等弊端以及核扩散风险。此外,全球实验反应堆为数不多且面临老化、退役问题,也多次因计划内的维修或意外停产事件而使99mTc供应面临困难。本文从99Mo/99mTc的供求现状入手,分析了目前供应链中存在的主要问题,重点介绍了六种传统及新型99Mo/99mTc生产技术的原理、研究进展及其经济性效益。详细评述了三种99Mo/99mTc分离纯化工艺,提出了99Mo/99mTc生产的发展趋势和展望。其中,以加速器驱动裂变低浓缩铀盐溶液的生产方式具有无反应堆、无高浓缩铀、放射性废物少等优势,是未来的重点研究方向。同时,为减少99Mo/99mTc损失,提高产品质量,开发和优化与生产体系相适应的分离纯化工艺也势在必行。中国科学院核能安全技术研究所FDS中科凤麟核能团队设计开发的一种氘氚聚变中子源驱动的99Mo次临界生产系统方案,可获得27Ci/d的99Mo产量,能满足国内一个中等省份的医疗诊断需求。
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出版历程
  • 收稿日期:  2018-09-26
  • 修回日期:  2019-02-15
  • 刊出日期:  2019-06-20

医用放射性同位素99Mo/99mTc生产现状和展望

doi: 10.11804/NuclPhysRev.36.02.170
    基金项目:  国家自然科学基金项目(11605232);安徽省自然科学基金项目(1808085MA10)
    作者简介:

    李紫微(1995-),女,河北保定人,在读研究生,从事医用放射性同位素研究;E-mail:ziwei.li@fds.org.cn

    通讯作者: 韩运成,E-mail:yuncheng.han@fds.org.cn
  • 中图分类号: TL92

摘要: 99mTc是目前临床诊断应用最为广泛的医用放射性同位素。现有医用99mTc主要通过在实验堆中辐照高浓缩235U生成的99Mo衰变得到,存在工艺复杂、成本高、长距离运输损失等弊端以及核扩散风险。此外,全球实验反应堆为数不多且面临老化、退役问题,也多次因计划内的维修或意外停产事件而使99mTc供应面临困难。本文从99Mo/99mTc的供求现状入手,分析了目前供应链中存在的主要问题,重点介绍了六种传统及新型99Mo/99mTc生产技术的原理、研究进展及其经济性效益。详细评述了三种99Mo/99mTc分离纯化工艺,提出了99Mo/99mTc生产的发展趋势和展望。其中,以加速器驱动裂变低浓缩铀盐溶液的生产方式具有无反应堆、无高浓缩铀、放射性废物少等优势,是未来的重点研究方向。同时,为减少99Mo/99mTc损失,提高产品质量,开发和优化与生产体系相适应的分离纯化工艺也势在必行。中国科学院核能安全技术研究所FDS中科凤麟核能团队设计开发的一种氘氚聚变中子源驱动的99Mo次临界生产系统方案,可获得27Ci/d的99Mo产量,能满足国内一个中等省份的医疗诊断需求。

English Abstract

李紫微, 韩运成, 王晓彧, 张佳辰, 王永峰, 黄群英. 医用放射性同位素99Mo/99mTc生产现状和展望[J]. 原子核物理评论, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
引用本文: 李紫微, 韩运成, 王晓彧, 张佳辰, 王永峰, 黄群英. 医用放射性同位素99Mo/99mTc生产现状和展望[J]. 原子核物理评论, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
LI Ziwei, HAN Yuncheng, WANG Xiaoyu, ZHANG Jiachen, WANG Yongfeng, HUANG Qunying. Production Status and Technical Prospects of Medical Radioisotope 99Mo/99mTc[J]. Nuclear Physics Review, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
Citation: LI Ziwei, HAN Yuncheng, WANG Xiaoyu, ZHANG Jiachen, WANG Yongfeng, HUANG Qunying. Production Status and Technical Prospects of Medical Radioisotope 99Mo/99mTc[J]. Nuclear Physics Review, 2019, 36(2): 170-183. doi: 10.11804/NuclPhysRev.36.02.170
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