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大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究

戴天缘 李强 陈卫强 刘新国 戴中颖

戴天缘, 李强, 陈卫强, 刘新国, 戴中颖. 大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究[J]. 原子核物理评论, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
引用本文: 戴天缘, 李强, 陈卫强, 刘新国, 戴中颖. 大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究[J]. 原子核物理评论, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
DAI Tianyuan, LI Qiang, CHEN Weiqiang, LIU Xinguo, DAI Zhongying. Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy[J]. Nuclear Physics Review, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
Citation: DAI Tianyuan, LI Qiang, CHEN Weiqiang, LIU Xinguo, DAI Zhongying. Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy[J]. Nuclear Physics Review, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784

大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究

doi: 10.11804/NuclPhysRev.34.04.784
基金项目: 国家自然科学基金委员会-中国科学院大科学装置联合基金资助项目(U1232207);国家科技支撑计划资助项目(2015BAI01B11);国家自然科学基金资助项目(11205217,11475231,11075191);国家重点研发计划资助项目(2016YFC0904600)
详细信息
    作者简介:

    戴天缘(1992-),男,黑龙江哈尔滨人,博士研究生,从事重离子治疗技术基础研究;E-mail:dty@impcas.ac.cn

    通讯作者: 李强,E-mail:liqiang@impcas.ac.cn。
  • 中图分类号: O571.53

Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy

Funds: Key Project of National Natural Science Foundation of China(U1232207);National Key Technology Support Program of Ministry of Science and Technology of China(2015BAI01B11);National Natural Science Foundation of China(11205217, 11475231, 11075191);National Key Research and Development Program of China(2016YFC0904600)
  • 摘要: 应用碳离子束进行大分割放射治疗从而缩短治疗周期是碳离子束治疗的优势之一。为研究大分割放疗增加单次照射剂量后,碳离子束相对生物学效应(RBE)的变化,应用细胞存活线性平方(LQ)模型推导出RBE与剂量的依赖关系。基于此关系研究了具有不同辐射敏感性的肿瘤细胞和正常组织细胞RBE随剂量的变化。结果表明,在0~20 Gy范围内,不论肿瘤细胞与正常组织细胞具有怎样的辐射敏感性,肿瘤细胞的RBE值始终大于正常组织细胞。此外,基于理论推导和对相关实验数据的分析,证实了RBE随剂量增加而递增现象的存在。这些结果对应用碳离子束进行大分割放射治疗具有重要的指导作用。


    Short treatment course due to the suitability of hypofractionated regimen for carbon ion beam is one of the advantages of carbon ion radiotherapy. To study the dependence of relative biological effectiveness (RBE) on dose, the relationship between RBE and dose was deduced through the linear-quadratic (LQ) model. Based on the relationship, the change of RBE of tumor cells and normal tissue cells with different radiosensitivities with dose was studied. The results showed that the RBE value of tumor cells was always greater than that of normal tissue cells in the dose range of 0~20 Gy, regardless of the radiosensitivity of tumor and normal tissue cells. In addition, based on theoretical deduction and analysis of the relevant experimental data, the existence of RBE increase with increasing dose was verified. These results are of great significance for conducting hypofractionated radiotherapy with carbon ion beam.
  • [1] TSUJⅡ H, KAMADA T, SHIRAI T, et al. Carbon-Ion Radiotherapy:Principles, Practices, and Treatment Planning[M]. Tokyo:Springer, 2014:13.
    [2] DELANEY T F, KOOY H M, et al. Proton and Charged Particle Radiotherapy[M]. Philadelphia:Wilkins, 2008:110.
    [3] MA L,ZHOU G X, FENG L C, et al. High LET (heavy ion and fast neutron) Malignant Tumors Therapeutic Radiology[M]. Beijing:Military Medicine Science Press, 2007:52. (in Chinese) (马林, 周桂霞, 冯林春, 等. 恶性肿瘤高LET(重离子, 快中子)放射治疗学[M]. 北京:军事医学科学出版社, 2007:52.)
    [4] CARABE-FERNANDEZ A, DALE R G, HOPEWELL J W, et al. Phys Med Biol, 2010, 55(19):5685.
    [5] DENEKAMP J, WAITES T, FOWLER J F, et al. Int J Radiat Biol, 1997, 71(6):681.
    [6] FRIEDRICH T, SCHOLZ U, DURANTE M, et al. Phys Med, 2014, 30(5):588.
    [7] FRESE M C, YU V K, STEWART R D, et al. Int J Radiat Oncol Biol Phys, 2012, 83(1):442.
    [8] ANDREO P, BURNS D T, HOHLFELD K, et al. IAEA TRS-398, 2001:124.
    [9] FURUSAWA Y, FUKUTSU K, AOKI M, et al. Radiation Research, 2000, 154(5):485.
    [10] K WEYRATHER SRMSW, et al. Int J Radiat Biol, 2009, 75(11):1357.
    [11] WANG J, LI R, GUO C, et al. Journal of Radiation Research, 2008, 49(4):391.
    [12] SUZUKI M, KASE Y, H, KANAI T, et al. International Journal of Radiation Oncology Biology Physics, 2000, 48(1):241.
    [13] SUZUKI M, KASE Y, H, KANAI T, et al. International Journal of Radiation Oncology Biology Physics, 2000, 48(1):251.
    [14] TSURUOKA C, SUZUKI M, KANAI T, et al. Radiation Research, 2005, 163(5):494.
    [15] AMORNWICHET N, OIKE T, SHIBATA A, et al. Plos One, 2014, 9(12).
    [16] MATSUMOTO Y, IWAKAWA M, FURUSAWA Y, et al. Int J Radiat Biol, 2008, 84(4):299.
    [17] MATSUZAKI H, MIYAMOTO T, MIYAZAWA Y, et al. Breast Cancer, 1998, 5(3):261.
    [18] OONISHI K, CUI X, HIRAKAWA H, et al. Radiother Oncol, 2012, 105(2):258.
    [19] TAKAHASHI A, MA H, NAKAGAWA A, et al. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 2014, 03(03):133.
    [20] HIRAYAMA R, UZAWA A, TAKASE N, et al. Mutat Res, 2013, 756(1-2):146.
    [21] BELLI M, BETTEGA D, CALZOLARI P, et al. Journal of Radiation Research, 2008, 49(6):597.
    [22] OGATA T, TESHIMA T, KAGAWA K, et al. Cancer Research, 2005, 65(1):113.
    [23] KITAJIMA S, NAKAMURA H, ADACHI M, et al. Journal of Radiation Research, 1997, 71(6):681.
    [24] DENEKAMP J, WAITES T, FOWLER JF, et al. Int J Radiat Biol, 2010, 5:251.
    [25] LIU X, LIU Y, LI Q, et al. Nuclear Physics Review, 2015, 32(4):473. (in Chinese) (刘玺, 刘岩, 李强. 原子核物理评论. 2015, 32(4):473.)
    [26] JIN X, LI F, ZHENG X, et al. Scientific Reports, 2015, 5:13815.
    [27] LIU Y, LIU X, JIN X, et al. Journal of Nanoscience & Nanotechnology, 2016, 16(3):2365.
    [28] ZHENG Y T, XIA Y F, QIAN J Y, et al. Chinese Journal of medical Physics, 1999, 16(3):194. (in Chinese) (郑云婷, 夏云飞, 钱剑扬. 中国医学物理学杂志. 1999, 16(3):194.)
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出版历程
  • 收稿日期:  2017-01-12
  • 修回日期:  2017-04-01
  • 刊出日期:  2017-12-20

大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究

doi: 10.11804/NuclPhysRev.34.04.784
    基金项目:  国家自然科学基金委员会-中国科学院大科学装置联合基金资助项目(U1232207);国家科技支撑计划资助项目(2015BAI01B11);国家自然科学基金资助项目(11205217,11475231,11075191);国家重点研发计划资助项目(2016YFC0904600)
    作者简介:

    戴天缘(1992-),男,黑龙江哈尔滨人,博士研究生,从事重离子治疗技术基础研究;E-mail:dty@impcas.ac.cn

    通讯作者: 李强,E-mail:liqiang@impcas.ac.cn。
  • 中图分类号: O571.53

摘要: 应用碳离子束进行大分割放射治疗从而缩短治疗周期是碳离子束治疗的优势之一。为研究大分割放疗增加单次照射剂量后,碳离子束相对生物学效应(RBE)的变化,应用细胞存活线性平方(LQ)模型推导出RBE与剂量的依赖关系。基于此关系研究了具有不同辐射敏感性的肿瘤细胞和正常组织细胞RBE随剂量的变化。结果表明,在0~20 Gy范围内,不论肿瘤细胞与正常组织细胞具有怎样的辐射敏感性,肿瘤细胞的RBE值始终大于正常组织细胞。此外,基于理论推导和对相关实验数据的分析,证实了RBE随剂量增加而递增现象的存在。这些结果对应用碳离子束进行大分割放射治疗具有重要的指导作用。


Short treatment course due to the suitability of hypofractionated regimen for carbon ion beam is one of the advantages of carbon ion radiotherapy. To study the dependence of relative biological effectiveness (RBE) on dose, the relationship between RBE and dose was deduced through the linear-quadratic (LQ) model. Based on the relationship, the change of RBE of tumor cells and normal tissue cells with different radiosensitivities with dose was studied. The results showed that the RBE value of tumor cells was always greater than that of normal tissue cells in the dose range of 0~20 Gy, regardless of the radiosensitivity of tumor and normal tissue cells. In addition, based on theoretical deduction and analysis of the relevant experimental data, the existence of RBE increase with increasing dose was verified. These results are of great significance for conducting hypofractionated radiotherapy with carbon ion beam.

English Abstract

戴天缘, 李强, 陈卫强, 刘新国, 戴中颖. 大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究[J]. 原子核物理评论, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
引用本文: 戴天缘, 李强, 陈卫强, 刘新国, 戴中颖. 大分割碳离子放射治疗中相对生物学效应与剂量依赖关系的研究[J]. 原子核物理评论, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
DAI Tianyuan, LI Qiang, CHEN Weiqiang, LIU Xinguo, DAI Zhongying. Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy[J]. Nuclear Physics Review, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
Citation: DAI Tianyuan, LI Qiang, CHEN Weiqiang, LIU Xinguo, DAI Zhongying. Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy[J]. Nuclear Physics Review, 2017, 34(4): 784-789. doi: 10.11804/NuclPhysRev.34.04.784
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