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基于MCNPX的重离子治癌相关问题研究

刘源源 吉尚戎 李金阳 骆鹏 张晖 李强

刘源源, 吉尚戎, 李金阳, 骆鹏, 张晖, 李强. 基于MCNPX的重离子治癌相关问题研究[J]. 原子核物理评论, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
引用本文: 刘源源, 吉尚戎, 李金阳, 骆鹏, 张晖, 李强. 基于MCNPX的重离子治癌相关问题研究[J]. 原子核物理评论, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
LIU Yuanyuan, JI Shangrong, LI Jinyang, LUO Peng, ZHANG Hui, LI Qiang. MCNPX-based Study on the Issues Related to Heavy Ion Cancer Therapy[J]. Nuclear Physics Review, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
Citation: LIU Yuanyuan, JI Shangrong, LI Jinyang, LUO Peng, ZHANG Hui, LI Qiang. MCNPX-based Study on the Issues Related to Heavy Ion Cancer Therapy[J]. Nuclear Physics Review, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236

基于MCNPX的重离子治癌相关问题研究

doi: 10.11804/NuclPhysRev.34.02.236
基金项目: 国家重点研发计划资助项目(2016YFC0904700);国家科技支撑计划资助项目(2015BAI01B11);国家自然科学基金资助项目(11205217,11075191)
详细信息
    作者简介:

    刘源源(1985-),女,内蒙古巴彦淖尔人,工程师,博士研究生,从事生物物理学研究;E-mail:liuyuanyuan@impcas.ac.cn

    通讯作者: 李强,E-mail:liqiang@impcas.ac.cn。
  • 中图分类号: R730.55

MCNPX-based Study on the Issues Related to Heavy Ion Cancer Therapy

Funds: National Key Research and Development Program of Ministry of Science and Technology of China (2016YFC0904700); National Key Technology Support Program of Ministry of Science and Technology of China(2015BAI01B11); National Natural Science Foundation of China(11205217, 11075191)
  • 摘要: 利用MCNPX模拟计算了医用重离子加速器示范装置(HIMM)上提供的碳离子束在水中的深度剂量分布,并与在HIMM装置上实验测量得到相应能量碳离子束的深度剂量分布进行比较,发现模拟结果与实验测量结果相符合,验证了MCNPX用于重离子输运模拟的准确性。开发了基于射线追踪技术的解析传输接口软件RTIM和基于PYDICOM的DCVM软件,将存储在DICOM文件中的补偿器信息和患者CT图像信息转化为MCNPX可识别的构造实体表示法信息,从而实现了在MCNPX中对重离子TPS产生的补偿器和患者CT图像建模。这些研究为利用MCNPX模拟HIMM被动式束流配送系统构形后的重离子束流在患者体内的剂量分布奠定了基础。


    The depth-dose distributions of different energy carbon ions provided by the demonstration facility of Heavy Ion Medical Machine (HIMM) in tissue-like medium water were calculated using the MCNPX Monte Carlo simulation code. The results derived from the simulation calculations were compared with those measured in the facility of HIMM and showed good agreement with the bexperimental data. Therefore, the usability of MCNPX for heavy ion transportation in tissue-like medium is verified. The present work also developed a parsed script transfer interface for MCNPX-(CSG) simulation based on ray casting technology and DCVM (Dose Calculation Viewer for MCNPX) code based on the PYDICOM code to convert the DICOM files of compensator and CT phantoms to corresponding CSG files that can be identified by MCNPX. Then modeling of the compensator and CT phantoms of HIMM in MCNPX was successfully performed. The present work provides a basis for MCNPX simulation for the dose distribution of carbon ions shaped by HIMM passive beam distribution system in patient date patient based on CT images.
  • [1] PTCOG homepage. Available online: http://www.ptcog.ch/[2016-07-04].
    [2] ROBERT C, DEDES G, BATTISTONI G, et al. Phys Med Biol, 2013, 58: 2879.
    [3] BOHLEN T T, DOSANJH M, FERRARI A, et al. Int J Radiat Biol, 2012, 88: 176.
    [4] FOSSATI P, MOLINELLI S, MATSUFUJI N, et al. Phys Med Biol, 2012, 57: 7543.
    [5] GUDOWSKA I, SOBOLEVSKY N, ANDREO P, et al. Phys Med Biol, 2004, 49: 1933.
    [6] GREGG W. KINNEY M C. MCNPX User's Manual, Ver-sion 2.7.0, Los Alamos National Laboratory report[M]. USA,Los Alamos National Laboratory report, 2011: 11-113.
    [7] LEE C C, LEE Y J, TUNG C J, et al. Radiation Physics and Chemistry, 2014, 95: 302.
    [8] CHAO T C, WEI S C, WU S W, et al. Radiation Physics and Chemistry, 2015, 116: 237.
    [9] MOWLAVI A A, FORNASIE M R, DENARO M D. Applied Radiation and Isotopes, 2011, 69(1): 122.
    [10] DIOSZEGI I, RUSEK A, DANE B R, et al. AIP Conference Proceedings, 2011, 1336: 406.
    [11] HARALD P, JIANG H Y, PARODI K, et al. Phys Med Biol,2008, 53: 4825.
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出版历程
  • 收稿日期:  2017-02-20
  • 修回日期:  2017-03-12
  • 刊出日期:  2017-06-20

基于MCNPX的重离子治癌相关问题研究

doi: 10.11804/NuclPhysRev.34.02.236
    基金项目:  国家重点研发计划资助项目(2016YFC0904700);国家科技支撑计划资助项目(2015BAI01B11);国家自然科学基金资助项目(11205217,11075191)
    作者简介:

    刘源源(1985-),女,内蒙古巴彦淖尔人,工程师,博士研究生,从事生物物理学研究;E-mail:liuyuanyuan@impcas.ac.cn

    通讯作者: 李强,E-mail:liqiang@impcas.ac.cn。
  • 中图分类号: R730.55

摘要: 利用MCNPX模拟计算了医用重离子加速器示范装置(HIMM)上提供的碳离子束在水中的深度剂量分布,并与在HIMM装置上实验测量得到相应能量碳离子束的深度剂量分布进行比较,发现模拟结果与实验测量结果相符合,验证了MCNPX用于重离子输运模拟的准确性。开发了基于射线追踪技术的解析传输接口软件RTIM和基于PYDICOM的DCVM软件,将存储在DICOM文件中的补偿器信息和患者CT图像信息转化为MCNPX可识别的构造实体表示法信息,从而实现了在MCNPX中对重离子TPS产生的补偿器和患者CT图像建模。这些研究为利用MCNPX模拟HIMM被动式束流配送系统构形后的重离子束流在患者体内的剂量分布奠定了基础。


The depth-dose distributions of different energy carbon ions provided by the demonstration facility of Heavy Ion Medical Machine (HIMM) in tissue-like medium water were calculated using the MCNPX Monte Carlo simulation code. The results derived from the simulation calculations were compared with those measured in the facility of HIMM and showed good agreement with the bexperimental data. Therefore, the usability of MCNPX for heavy ion transportation in tissue-like medium is verified. The present work also developed a parsed script transfer interface for MCNPX-(CSG) simulation based on ray casting technology and DCVM (Dose Calculation Viewer for MCNPX) code based on the PYDICOM code to convert the DICOM files of compensator and CT phantoms to corresponding CSG files that can be identified by MCNPX. Then modeling of the compensator and CT phantoms of HIMM in MCNPX was successfully performed. The present work provides a basis for MCNPX simulation for the dose distribution of carbon ions shaped by HIMM passive beam distribution system in patient date patient based on CT images.

English Abstract

刘源源, 吉尚戎, 李金阳, 骆鹏, 张晖, 李强. 基于MCNPX的重离子治癌相关问题研究[J]. 原子核物理评论, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
引用本文: 刘源源, 吉尚戎, 李金阳, 骆鹏, 张晖, 李强. 基于MCNPX的重离子治癌相关问题研究[J]. 原子核物理评论, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
LIU Yuanyuan, JI Shangrong, LI Jinyang, LUO Peng, ZHANG Hui, LI Qiang. MCNPX-based Study on the Issues Related to Heavy Ion Cancer Therapy[J]. Nuclear Physics Review, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
Citation: LIU Yuanyuan, JI Shangrong, LI Jinyang, LUO Peng, ZHANG Hui, LI Qiang. MCNPX-based Study on the Issues Related to Heavy Ion Cancer Therapy[J]. Nuclear Physics Review, 2017, 34(2): 236-241. doi: 10.11804/NuclPhysRev.34.02.236
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