GANRA-5对X射线和<SUP>12</SUP>C<SUP>6+</SUP>离子辐射防护作用研究

姜林; 裴海龙; 朱明月; 刘婷婷; 徐丹; 孙放; 张栩锐; 丁楠; 胡文涛; 王菊芳; 周光明

doi:10.11804/NuclPhysRev.31.03.423

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

姜林, 裴海龙, 朱明月, 刘婷婷, 徐丹, 孙放, 张栩锐, 丁楠, 胡文涛, 王菊芳, 周光明

文章导航 > 原子核物理评论 > 2014 > 31(3): 423-427

姜林, 裴海龙, 朱明月, 刘婷婷, 徐丹, 孙放, 张栩锐, 丁楠, 胡文涛, 王菊芳, 周光明. GANRA-5对X射线和12C6+离子辐射防护作用研究[J]. 原子核物理评论, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423

引用本文:

姜林, 裴海龙, 朱明月, 刘婷婷, 徐丹, 孙放, 张栩锐, 丁楠, 胡文涛, 王菊芳, 周光明. GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究[J]. 原子核物理评论, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423

JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and 12C6+[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423

Citation:

JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

doi: 10.11804/NuclPhysRev.31.03.423

中国工程物理研究院核物理与化学研究所,四川绵阳 621900;
中国科学院近代物理研究所,兰州 730000;
中国科学院大学,北京 100049

Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺

Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics,Mianyang 621900, Sichuan, China;
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

摘要: 研究了一种新的恶唑酮类衍生物GANRA-5 对于人胚肺细胞MRC-5 的辐射防护作用。以MTT评价其对于细胞的毒性，以H2AX foci 形成法检测其对于辐照后细胞中双链断裂的影响，发现其对于受到X射线和¹²C⁶⁺离子照射的细胞具有较强的辐射防护作用，并进一步发现其能够显著清除辐照后细胞内的自由基。这些结果表明，GANRA-5 具有较低的细胞毒性，并能够通过清除自由基发挥较强的针对X射线和¹²C⁶⁺离子的辐射防护作用，有望开发为高效的辐射防护药物。The radio-protective effects on human embryonic lung fibroblast MRC-5 of an oxazolone derivative named GANRA-5 were studied. MTT test was used to evaluate the toxicity and H2AX foci assay was used to test the influence of GANRA-5 on the DSB (double-stranded break) formation after irradiation. It is found that GANRA-5 exhibited low toxicity and high radio-protective effects on MRC-5 cells against both X-ray and ¹²C⁶⁺ ion beam. It is also found that it can act as a scavenger of free radicals. These results suggest that GANRA-5 is a promising radioprotectant.
- GANRA-5 /
- 辐射防护 /
- 自由基
Abstract: The radio-protective effects on human embryonic lung fibroblast MRC-5 of an oxazolone derivative named GANRA-5 were studied. MTT test was used to evaluate the toxicity and H2AX foci assay was used to test the influence of GANRA-5 on the DSB (double-stranded break) formation after irradiation. It is found that GANRA-5 exhibited low toxicity and high radio-protective effects on MRC-5 cells against both X-ray and ¹²C⁶⁺ ion beam. It is also found that it can act as a scavenger of free radicals. These results suggest that GANRA-5 is a promising radioprotectant.
- GANRA-5 /
- radio-protection /
- free radical

点击查看大图

计量

文章访问数: 1769
HTML全文浏览量: 89
PDF下载量: 324
被引次数: 0

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

doi: 10.11804/NuclPhysRev.31.03.423

中国工程物理研究院核物理与化学研究所,四川绵阳 621900;

中国科学院近代物理研究所,兰州 730000;

中国科学院大学,北京 100049

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2014-09-20

关键词:

GANRA-5 /

辐射防护 /

自由基

摘要: 研究了一种新的恶唑酮类衍生物GANRA-5 对于人胚肺细胞MRC-5 的辐射防护作用。以MTT评价其对于细胞的毒性，以H2AX foci 形成法检测其对于辐照后细胞中双链断裂的影响，发现其对于受到X射线和¹²C⁶⁺离子照射的细胞具有较强的辐射防护作用，并进一步发现其能够显著清除辐照后细胞内的自由基。这些结果表明，GANRA-5 具有较低的细胞毒性，并能够通过清除自由基发挥较强的针对X射线和¹²C⁶⁺离子的辐射防护作用，有望开发为高效的辐射防护药物。The radio-protective effects on human embryonic lung fibroblast MRC-5 of an oxazolone derivative named GANRA-5 were studied. MTT test was used to evaluate the toxicity and H2AX foci assay was used to test the influence of GANRA-5 on the DSB (double-stranded break) formation after irradiation. It is found that GANRA-5 exhibited low toxicity and high radio-protective effects on MRC-5 cells against both X-ray and ¹²C⁶⁺ ion beam. It is also found that it can act as a scavenger of free radicals. These results suggest that GANRA-5 is a promising radioprotectant.

English Abstract

引用本文:

Citation:

JIANG Lin, PEI Hailong, ZHU Mingyue, LIU Tingting, XU Dan, SUN Fang, ZHANG Xurui, DING Nan, HU Wentao, WANG Jufang, ZHOU Guangming. Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺[J]. Nuclear Physics Review, 2014, 31(3): 423-427. doi: 10.11804/NuclPhysRev.31.03.423

全文HTML

下载: 全尺寸图片幻灯片

返回文章

用微信扫码二维码

分享至好友和朋友圈

留言板

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

doi: 10.11804/NuclPhysRev.31.03.423

Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺

计量

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

doi: 10.11804/NuclPhysRev.31.03.423

中国工程物理研究院核物理与化学研究所,四川绵阳 621900;

中国科学院近代物理研究所,兰州 730000;

中国科学院大学,北京 100049

English Abstract

Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺

Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics,Mianyang 621900, Sichuan, China;

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

全文HTML

目录

留言板

GANRA-5对X射线和12C6+离子辐射防护作用研究

doi: 10.11804/NuclPhysRev.31.03.423

Radioprotective Effects of GANRA-5 to X-rays and 12C6+

计量

出版历程

GANRA-5对X射线和12C6+离子辐射防护作用研究

doi: 10.11804/NuclPhysRev.31.03.423

中国工程物理研究院核物理与化学研究所,四川 绵阳 621900; 中国科学院近代物理研究所,兰州 730000; 中国科学院大学,北京 100049

English Abstract

Radioprotective Effects of GANRA-5 to X-rays and 12C6+

Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics,Mianyang 621900, Sichuan, China; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

全文HTML

目录

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺

GANRA-5对X射线和¹²C⁶⁺离子辐射防护作用研究

中国工程物理研究院核物理与化学研究所,四川绵阳 621900;

中国科学院近代物理研究所,兰州 730000;

中国科学院大学,北京 100049

Radioprotective Effects of GANRA-5 to X-rays and ¹²C⁶⁺

Institute of Nuclear Physics and Chemistry, Chinese Academy of Engineering Physics,Mianyang 621900, Sichuan, China;

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;