Survivin表达在高LET射线诱导细胞凋亡中

金晓东; 李强; 吴庆丰; 李萍; 陶家军; 巩莉; 戴中颍; 刘新国

doi:10.11804/NuclPhysRev.27.02.202

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Survivin表达在高LET射线诱导细胞凋亡中

金晓东, 李强, 吴庆丰, 李萍, 陶家军, 巩莉, 戴中颍, 刘新国

文章导航 > 原子核物理评论 > 2010 > 27(2): 202-205

金晓东, 李强, 吴庆丰, 李萍, 陶家军, 巩莉, 戴中颍, 刘新国. Survivin表达在高LET射线诱导细胞凋亡中[J]. 原子核物理评论, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202

引用本文:

Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202

Citation:

Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202

Survivin表达在高LET射线诱导细胞凋亡中

doi: 10.11804/NuclPhysRev.27.02.202

1 中国科学院近代物理研究所, 甘肃兰州 730000; 2 中国科学院重离子束辐射生物医学重点实验室, 甘肃兰州 730000; 3 中国科学院研究生院, 北京 100049

A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;3 Graduate University of Chinese Academy of Sciences, Beijing 100049, China

摘要: 先前的研究表明，肿瘤细胞中survivin的高表达与细胞对高传能线密度(LET)射线的辐射抗性相关。研究了survivin表达在高LET射线诱导的细胞凋亡中的作用，发现抑制survivin表达对高LET C离子辐射诱导的Bcl-2和Bax表达没有明显的影响。在高LET射线辐照中， survivin可能通过抑制caspase-3和-9活性的途径，抑制了细胞凋亡。It has been proven that overexpression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study， action mechanisms of survivin gene in apoptosis induced by highLET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.
- 高LET射线 /
- 凋亡 /
- survivin
Abstract: It has been proven that over expression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study，action mechanisms of survivin gene in apoptosis induced by high LET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.
- highLET radiation /
- apoptosis /
- survivin

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Survivin表达在高LET射线诱导细胞凋亡中

doi: 10.11804/NuclPhysRev.27.02.202

1 中国科学院近代物理研究所, 甘肃兰州 730000; 2 中国科学院重离子束辐射生物医学重点实验室, 甘肃兰州 730000; 3 中国科学院研究生院, 北京 100049

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2010-06-20

关键词:

高LET射线 /

凋亡 /

survivin

摘要: 先前的研究表明，肿瘤细胞中survivin的高表达与细胞对高传能线密度(LET)射线的辐射抗性相关。研究了survivin表达在高LET射线诱导的细胞凋亡中的作用，发现抑制survivin表达对高LET C离子辐射诱导的Bcl-2和Bax表达没有明显的影响。在高LET射线辐照中， survivin可能通过抑制caspase-3和-9活性的途径，抑制了细胞凋亡。It has been proven that overexpression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study， action mechanisms of survivin gene in apoptosis induced by highLET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.

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引用本文:

Citation:

Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202

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Survivin表达在高LET射线诱导细胞凋亡中

doi: 10.11804/NuclPhysRev.27.02.202

A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

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Survivin表达在高LET射线诱导细胞凋亡中

doi: 10.11804/NuclPhysRev.27.02.202

1 中国科学院近代物理研究所, 甘肃 兰州 730000; 2 中国科学院重离子束辐射生物医学重点实验室, 甘肃 兰州 730000; 3 中国科学院研究生院, 北京 100049

English Abstract

A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;3 Graduate University of Chinese Academy of Sciences, Beijing 100049, China

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1 中国科学院近代物理研究所, 甘肃兰州 730000; 2 中国科学院重离子束辐射生物医学重点实验室, 甘肃兰州 730000; 3 中国科学院研究生院, 北京 100049