关键词: 
端粒酶 /
肿瘤 /
放射治疗

摘要: 随着端粒酶活性与肿瘤病理学关系的明确，对端粒酶与肿瘤关系的研究成为生物学研究领域的热点问题之一。 对端粒酶活性与肿瘤的关系，以及各种射线，特别是重离子辐照肿瘤后端粒酶活性的变化等最新研究成果进行了综述。 同时指出由于研究结论的矛盾，试图通过抑制端粒酶活性以杀死肿瘤，最终实现癌症治疗的方案是否可行，端粒酶活性的检测是否能作为放射肿瘤治疗效果有效性的指标还需要更深入的探讨。
The study on the relationship between telomerase and tumor become one of hotspots in biology because of its function in tumorigenesis. We reviewed the changes of telomerase activity of cancer cells irradiated by different radiations, especially heavy ion. Meanwhile, because of contradictory results, we should be cautious to the application of telomerase inhibition to kill tumor cell and thought deeply about evaluating the killing effect of adiotherapy by telomerase activity index.