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不同LET射线对细胞的生物学效应

荆西刚 李文建 杨建设 王转子 魏巍

荆西刚, 李文建, 杨建设, 王转子, 魏巍. 不同LET射线对细胞的生物学效应[J]. 原子核物理评论, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259
引用本文: 荆西刚, 李文建, 杨建设, 王转子, 魏巍. 不同LET射线对细胞的生物学效应[J]. 原子核物理评论, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259
JING Xi-gang, LI Wen-jian, YANG Jian-she, WANG Zhuan-zi, WEI Wei. Radiobiological Response of Cells Exposed to Radiations with Different LET[J]. Nuclear Physics Review, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259
Citation: JING Xi-gang, LI Wen-jian, YANG Jian-she, WANG Zhuan-zi, WEI Wei. Radiobiological Response of Cells Exposed to Radiations with Different LET[J]. Nuclear Physics Review, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259

不同LET射线对细胞的生物学效应

doi: 10.11804/NuclPhysRev.26.03.259

Radiobiological Response of Cells Exposed to Radiations with Different LET

  • 摘要: 以人肝癌细胞系和正常肝细胞系为材料,报道了不同传能线密度射线辐射引发细胞染色体原初断裂及24 h内的修复情况。 计算了相对生物学效应的值。 以L02染色体总断裂数量得出的RBE值96.05 keV/μm的12C6+ 为3.6, 512 keV/μm 36Ar18+ 为2.9。 而以7721染色体总断裂数量得出的RBE值: 96.05 keV/μm的12C6+ 为3.5,512keV/μm 36Ar18+也为2.9。用产生等点染色单体断裂计算,则RBE更高。对比得出,高LET对增加等点染色单体断裂量的作用要远远大于对增加染色单体断裂量的作用。等点染色单体的断裂修复难度要远远大于染色单体断裂的修复难度, 这也是高LET高致死率的一个重要原因。 Human hepatoma SMMC7721 and normal liver L02 cells were irradiated with γrays,12C6+ and 36Ar18+ ion beams at the Heavy Ion Research Facility in Lanzhou(HIRFL). We reported the kinetic repair of chromosome breaks of L02 and SMMC7721 cells in 24 h of postirradiation time. The relative biological effectiveness(RBE) for inducing chromatid breaks were 3.6 for L02 and 3.5 for SMMC7721 cell lines at the linear energy transfer(LET) peak of 96.55 keV/μm 12C6+ ions, and 2.9 (both of the two cell lines) at 512 keV/μm 36Ar18+ ions.It suggested that the RBE of isochromatidtype breaks induced by 36Ar18+ was higher than those by 12C6+. We concluded that the high production of isochromatidtype breaks, induced by the densely ionizing track structure, could be regarded as a signature of high LET radiation exposure.
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出版历程
  • 收稿日期:  1900-01-01
  • 修回日期:  1900-01-01
  • 刊出日期:  2009-09-20

不同LET射线对细胞的生物学效应

doi: 10.11804/NuclPhysRev.26.03.259

摘要: 以人肝癌细胞系和正常肝细胞系为材料,报道了不同传能线密度射线辐射引发细胞染色体原初断裂及24 h内的修复情况。 计算了相对生物学效应的值。 以L02染色体总断裂数量得出的RBE值96.05 keV/μm的12C6+ 为3.6, 512 keV/μm 36Ar18+ 为2.9。 而以7721染色体总断裂数量得出的RBE值: 96.05 keV/μm的12C6+ 为3.5,512keV/μm 36Ar18+也为2.9。用产生等点染色单体断裂计算,则RBE更高。对比得出,高LET对增加等点染色单体断裂量的作用要远远大于对增加染色单体断裂量的作用。等点染色单体的断裂修复难度要远远大于染色单体断裂的修复难度, 这也是高LET高致死率的一个重要原因。 Human hepatoma SMMC7721 and normal liver L02 cells were irradiated with γrays,12C6+ and 36Ar18+ ion beams at the Heavy Ion Research Facility in Lanzhou(HIRFL). We reported the kinetic repair of chromosome breaks of L02 and SMMC7721 cells in 24 h of postirradiation time. The relative biological effectiveness(RBE) for inducing chromatid breaks were 3.6 for L02 and 3.5 for SMMC7721 cell lines at the linear energy transfer(LET) peak of 96.55 keV/μm 12C6+ ions, and 2.9 (both of the two cell lines) at 512 keV/μm 36Ar18+ ions.It suggested that the RBE of isochromatidtype breaks induced by 36Ar18+ was higher than those by 12C6+. We concluded that the high production of isochromatidtype breaks, induced by the densely ionizing track structure, could be regarded as a signature of high LET radiation exposure.

English Abstract

荆西刚, 李文建, 杨建设, 王转子, 魏巍. 不同LET射线对细胞的生物学效应[J]. 原子核物理评论, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259
引用本文: 荆西刚, 李文建, 杨建设, 王转子, 魏巍. 不同LET射线对细胞的生物学效应[J]. 原子核物理评论, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259
JING Xi-gang, LI Wen-jian, YANG Jian-she, WANG Zhuan-zi, WEI Wei. Radiobiological Response of Cells Exposed to Radiations with Different LET[J]. Nuclear Physics Review, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259
Citation: JING Xi-gang, LI Wen-jian, YANG Jian-she, WANG Zhuan-zi, WEI Wei. Radiobiological Response of Cells Exposed to Radiations with Different LET[J]. Nuclear Physics Review, 2009, 26(3): 259-262. doi: 10.11804/NuclPhysRev.26.03.259

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