辐射致DNA损伤及相关生物-化学-物理问题(英文)

曹天光; 蔡明辉; 耿金鹏; 孔福全; 马云志; 卓益忠

doi:10.11804/NuclPhysRev.22.04.398

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辐射致DNA损伤及相关生物-化学-物理问题(英文)

曹天光, 蔡明辉, 耿金鹏, 孔福全, 马云志, 卓益忠

文章导航 > 原子核物理评论 > 2005 > 22(4): 398-401

曹天光, 蔡明辉, 耿金鹏, 孔福全, 马云志, 卓益忠. 辐射致DNA损伤及相关生物-化学-物理问题(英文)[J]. 原子核物理评论, 2005, 22(4): 398-401. doi: 10.11804/NuclPhysRev.22.04.398

引用本文:

CAO Tian-guang, CAI Ming-hui, GENG Jin-peng, KONG Fu-quan, MA Yun-zhi, ZHUO Yi-zhong. Radiation Induced DNA Damage and Related Bio-chemi-physical Problems[J]. Nuclear Physics Review, 2005, 22(4): 398-401. doi: 10.11804/NuclPhysRev.22.04.398

Citation:

CAO Tian-guang, CAI Ming-hui, GENG Jin-peng, KONG Fu-quan, MA Yun-zhi, ZHUO Yi-zhong. Radiation Induced DNA Damage and Related Bio-chemi-physical Problems[J]. Nuclear Physics Review, 2005, 22(4): 398-401. doi: 10.11804/NuclPhysRev.22.04.398

辐射致DNA损伤及相关生物-化学-物理问题(英文)

doi: 10.11804/NuclPhysRev.22.04.398

[1]中国原子能科学研究院,北京102413 [2]河北工业大学物理系,天津300130 [3]郑州大学物理工程学院,河南郑州450052 [4]北京大学物理学院,北京100871

Radiation Induced DNA Damage and Related Bio-chemi-physical Problems

1 China Institute of Atomic Energy, Beijing 102413, China; 2 Department of Physics, Hebei University of Technology, Tianjin 300130, China; 3 School of Physical Science and Engineering, Zhengzhou University, Zhengzhou 450052, China; 4 School of Physics, Peking University, Beijing 100871, China

摘要: 介绍了在DNA辐射损伤以及相关生物、物理、化学问题的一些研究工作。重点是径迹结构、DNA双链断裂和细胞学终点的关系。P53-Mdm2负反馈回路在DNA损伤的细胞响应方面起重要作用，用一个简单的模型研究了P53-Mdm2负反馈回路相互作用的动力学行为。Some of recent works are presented on radiation induced DNA damage being carried out at China Institute of Atomic Energy （CIAE） and related bio-chemi-physical problems. Emphasis is placed on track structure and its relation to the cell end-point, and a simple model proposed to study the dynamical behavior of P53-Mdm2 interaction which plays pivotal role in cellular response to DNA damage.
- 径迹结构 /
- 存活率 /
- 负反馈回路
Abstract: Some of recent works are presented on radiation induced DNA damage being carried out at China Institute of Atomic Energy （CIAE） and related bio-chemi-physical problems. Emphasis is placed on track structure and its relation to the cell end-point, and a simple model proposed to study the dynamical behavior of P53-Mdm2 interaction which plays pivotal role in cellular response to DNA damage.
- track structure /
- survival probability /
- negative feedback loop

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辐射致DNA损伤及相关生物-化学-物理问题(英文)

doi: 10.11804/NuclPhysRev.22.04.398

[1]中国原子能科学研究院,北京102413 [2]河北工业大学物理系,天津300130 [3]郑州大学物理工程学院,河南郑州450052 [4]北京大学物理学院,北京100871

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2005-12-20

关键词:

径迹结构 /

存活率 /

负反馈回路

摘要: 介绍了在DNA辐射损伤以及相关生物、物理、化学问题的一些研究工作。重点是径迹结构、DNA双链断裂和细胞学终点的关系。P53-Mdm2负反馈回路在DNA损伤的细胞响应方面起重要作用，用一个简单的模型研究了P53-Mdm2负反馈回路相互作用的动力学行为。Some of recent works are presented on radiation induced DNA damage being carried out at China Institute of Atomic Energy （CIAE） and related bio-chemi-physical problems. Emphasis is placed on track structure and its relation to the cell end-point, and a simple model proposed to study the dynamical behavior of P53-Mdm2 interaction which plays pivotal role in cellular response to DNA damage.