低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应

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低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应

夏景光, 李文建, 王菊芳, 郭传玲, 魏巍, 杨建设

文章导航 > 原子核物理评论 > 2005 > 22(2): 216-218

夏景光, 李文建, 王菊芳, 郭传玲, 魏巍, 杨建设. 低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应[J]. 原子核物理评论, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

引用本文:

夏景光, 李文建, 王菊芳, 郭传玲, 魏巍, 杨建设. 低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应[J]. 原子核物理评论, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

XIA Jing-guang, LI Wen-jian, WANG Ju-fang, GUO Chuan-ling, WEI Wei, YANG Jian-she. Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γray to hep G2 Cells[J]. Nuclear Physics Review, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

Citation:

XIA Jing-guang, LI Wen-jian, WANG Ju-fang, GUO Chuan-ling, WEI Wei, YANG Jian-she. Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γray to hep G2 Cells[J]. Nuclear Physics Review, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应

doi: 10.11804/NuclPhysRev.22.02.216

1 中国科学院近代物理研究所, 甘肃兰州 730000;2 中国科学院研究生院, 北京 100039

Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γray to hep G2 Cells

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100039, China

摘要: 以低剂量γ射线(0.05 Gy)预照射人肝癌细胞hep G2， 8 h后再用高剂量(3 Gy)照射，测定了细胞的克隆存活率和细胞周期。结果表明，低剂量辐射预处理可诱导hep G2细胞产生克隆存活适应性反应，并且有助于细胞通过G2/M期阻滞；低剂量辐射诱导的克隆存活适应性反应与增强的通过细胞周期阻滞的能力之间有一定的相关性。
Human hepatoma cells hep G2 were irradiated with 3 Gy of γray 8 hours after primed with 0.05 Gy of γray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by preirradiation with low dose of γray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest.
- 低剂量辐射 /
- 细胞周期阻滞 /
- 适应性反应
Abstract: Human hepatoma cells hep G2 were irradiated with 3 Gy of γray 8 hours after primed with 0.05 Gy of γray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by preirradiation with low dose of γray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest.
- low dose radiation /
- cell cycle arrest /
- adaptive response

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低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应

doi: 10.11804/NuclPhysRev.22.02.216

1 中国科学院近代物理研究所, 甘肃兰州 730000;2 中国科学院研究生院, 北京 100039

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2005-06-20

关键词:

低剂量辐射 /

细胞周期阻滞 /

适应性反应

摘要: 以低剂量γ射线(0.05 Gy)预照射人肝癌细胞hep G2， 8 h后再用高剂量(3 Gy)照射，测定了细胞的克隆存活率和细胞周期。结果表明，低剂量辐射预处理可诱导hep G2细胞产生克隆存活适应性反应，并且有助于细胞通过G2/M期阻滞；低剂量辐射诱导的克隆存活适应性反应与增强的通过细胞周期阻滞的能力之间有一定的相关性。
Human hepatoma cells hep G2 were irradiated with 3 Gy of γray 8 hours after primed with 0.05 Gy of γray， thereafter，cell survival and cell cycle were determined. The results indicated that both survival adaptive response and the enhanced ability to overcome G2/M arrest could be induced by preirradiation with low dose of γray. It is suggested that there is a certain correlation between the survival adaptive response and the enhanced ability to overcome cell cycle arrest.

English Abstract

夏景光, 李文建, 王菊芳, 郭传玲, 魏巍, 杨建设. 低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应[J]. 原子核物理评论, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

引用本文:

夏景光, 李文建, 王菊芳, 郭传玲, 魏巍, 杨建设. 低剂量辐射诱导hepG2细胞克隆存活和细胞周期适应性反应[J]. 原子核物理评论, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

XIA Jing-guang, LI Wen-jian, WANG Ju-fang, GUO Chuan-ling, WEI Wei, YANG Jian-she. Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γray to hep G2 Cells[J]. Nuclear Physics Review, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

Citation:

XIA Jing-guang, LI Wen-jian, WANG Ju-fang, GUO Chuan-ling, WEI Wei, YANG Jian-she. Adaptive Response for Survival and Cell Cycle Arrest Induced by Pre-irradiation with Low Dose of γray to hep G2 Cells[J]. Nuclear Physics Review, 2005, 22(2): 216-218. doi: 10.11804/NuclPhysRev.22.02.216

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