DNA双链断裂产额的新算法

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DNA双链断裂产额的新算法

周光明, 李文建, 高清祥, 卫增泉

文章导航 > 原子核物理评论 > 2003 > 20(1): 52-54

周光明, 李文建, 高清祥, 卫增泉. DNA双链断裂产额的新算法[J]. 原子核物理评论, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

引用本文:

周光明, 李文建, 高清祥, 卫增泉. DNA双链断裂产额的新算法[J]. 原子核物理评论, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

ZHOU Guang-ming, LI Wen-jian, GAO Qing-xiang, WEI Zeng-quan. A New Method for Calculating Yield of DNA Double-strand Breaks[J]. Nuclear Physics Review, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

Citation:

ZHOU Guang-ming, LI Wen-jian, GAO Qing-xiang, WEI Zeng-quan. A New Method for Calculating Yield of DNA Double-strand Breaks[J]. Nuclear Physics Review, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

DNA双链断裂产额的新算法

doi: 10.11804/NuclPhysRev.20.01.052

1 中国科学院近代物理研究所; 甘肃兰州730000;2 兰州大学生命科学学院; 甘肃兰州730000;

A New Method for Calculating Yield of DNA Double-strand Breaks

1 Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou 730000; China; 2 School of Life Science; Lanzhou University; China);

摘要: DNA双链断裂(DSB)的定量分析是高传能线密度辐射生物学效应机理研究的重要手段.从实际应用出发,推导了一个新的计算公式———平均分子量法.该法不探究DSB片段的具体分布模式,实际操作中却又包含了片段的含量和分布;而且形式简单、操作简便,尤其适合于荧光扫描数据. Quantitive analysis of DNA doublestrand break (DSB) is of importance for studying on the mechanisms of radiobiological effects induced by high linear energy transfer(LET) irradiation. For the practical use, one new calculating formula named the method of average molecular weight is deducted. In this method, the factual distribution of DSB fragments is not considered, but actually, the content and distribution of DSB fragments are included. Totally, this method is simple in shape and easy to use, esp...
- DNA双链断裂 /
- 高传能线密度辐照 /
- 生物学效应 /
- 计算方法
Abstract: Quantitive analysis of DNA doublestrand break (DSB) is of importance for studying on the mechanisms of radiobiological effects induced by high linear energy transfer(LET) irradiation. For the practical use, one new calculating formula named the method of average molecular weight is deducted. In this method, the factual distribution of DSB fragments is not considered, but actually, the content and distribution of DSB fragments are included. Totally, this method is simple in shape and easy to use, esp...
- DNA double-strand break /
- high linear energy transfer irradiation /
- biological effect /
- calculating method

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DNA双链断裂产额的新算法

doi: 10.11804/NuclPhysRev.20.01.052

1 中国科学院近代物理研究所; 甘肃兰州730000;2 兰州大学生命科学学院; 甘肃兰州730000;

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2003-03-20

关键词:

DNA双链断裂 /

高传能线密度辐照 /

生物学效应 /

摘要: DNA双链断裂(DSB)的定量分析是高传能线密度辐射生物学效应机理研究的重要手段.从实际应用出发,推导了一个新的计算公式———平均分子量法.该法不探究DSB片段的具体分布模式,实际操作中却又包含了片段的含量和分布;而且形式简单、操作简便,尤其适合于荧光扫描数据. Quantitive analysis of DNA doublestrand break (DSB) is of importance for studying on the mechanisms of radiobiological effects induced by high linear energy transfer(LET) irradiation. For the practical use, one new calculating formula named the method of average molecular weight is deducted. In this method, the factual distribution of DSB fragments is not considered, but actually, the content and distribution of DSB fragments are included. Totally, this method is simple in shape and easy to use, esp...

English Abstract

周光明, 李文建, 高清祥, 卫增泉. DNA双链断裂产额的新算法[J]. 原子核物理评论, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

引用本文:

周光明, 李文建, 高清祥, 卫增泉. DNA双链断裂产额的新算法[J]. 原子核物理评论, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

ZHOU Guang-ming, LI Wen-jian, GAO Qing-xiang, WEI Zeng-quan. A New Method for Calculating Yield of DNA Double-strand Breaks[J]. Nuclear Physics Review, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

Citation:

ZHOU Guang-ming, LI Wen-jian, GAO Qing-xiang, WEI Zeng-quan. A New Method for Calculating Yield of DNA Double-strand Breaks[J]. Nuclear Physics Review, 2003, 20(1): 52-54. doi: 10.11804/NuclPhysRev.20.01.052

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