重离子辐射哺乳动物细胞敏感性的分子机理

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重离子辐射哺乳动物细胞敏感性的分子机理

李文建, 周光明, 卫增泉, 王菊芳, 李强, 党秉荣, 颉红梅

文章导航 > 原子核物理评论 > 2003 > 20(1): 42-47

李文建, 周光明, 卫增泉, 王菊芳, 李强, 党秉荣, 颉红梅. 重离子辐射哺乳动物细胞敏感性的分子机理[J]. 原子核物理评论, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

引用本文:

李文建, 周光明, 卫增泉, 王菊芳, 李强, 党秉荣, 颉红梅. 重离子辐射哺乳动物细胞敏感性的分子机理[J]. 原子核物理评论, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

LI Wen-jian, ZHOU Guang-ming, WEI Zeng-quan, WANG Ju-fang, LI Qiang, DANG Bing-rong, XIE Hong-mei. A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions[J]. Nuclear Physics Review, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

Citation:

LI Wen-jian, ZHOU Guang-ming, WEI Zeng-quan, WANG Ju-fang, LI Qiang, DANG Bing-rong, XIE Hong-mei. A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions[J]. Nuclear Physics Review, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

重离子辐射哺乳动物细胞敏感性的分子机理

doi: 10.11804/NuclPhysRev.20.01.042

中国科学院近代物理研究所甘肃兰州730000;

A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions

Institute of Modern Physics; Chinese Academy of Sciences; Lanzhou 730000; China ;

摘要: 研究了用传能线密度125.5keV/μm的¹²C⁶⁺辐照小鼠黑色素瘤、中国仓鼠肺、人的宫颈癌、人的肝癌细胞的敏感性以及DNA双链断裂和DNA双链断裂片段分布,结果表明细胞敏感性与DNA双链断裂之间没有一致的关系,提出了细胞辐射敏感性的一种可能的分子机理,即DNA序列敏感性位点协同DNA双链断裂互补性机理.由此解释了4种细胞系的不同敏感性问题. Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...
- 重离子 /
- 哺乳动物细胞 /
- 辐射敏感性 /
- 分子机理
Abstract: Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...
- heavy ion /
- mammalian cell /
- radiosensitivity /
- mechanism

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重离子辐射哺乳动物细胞敏感性的分子机理

doi: 10.11804/NuclPhysRev.20.01.042

中国科学院近代物理研究所甘肃兰州730000;

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2003-03-20

关键词:

哺乳动物细胞 /

辐射敏感性 /

摘要: 研究了用传能线密度125.5keV/μm的¹²C⁶⁺辐照小鼠黑色素瘤、中国仓鼠肺、人的宫颈癌、人的肝癌细胞的敏感性以及DNA双链断裂和DNA双链断裂片段分布,结果表明细胞敏感性与DNA双链断裂之间没有一致的关系,提出了细胞辐射敏感性的一种可能的分子机理,即DNA序列敏感性位点协同DNA双链断裂互补性机理.由此解释了4种细胞系的不同敏感性问题. Four types of cells, melanoma B16, cervical squamous carcinima HeLa, Chinese hamster V79 and hepatoma SMMC7721, were irradiated by 125.5 keV/μm carbon ions. Celullar sensitivities to irradiation indicated by D50 , DNA double strand break (DSB) and distribution of DSB fragments expressed by molecular weight are studied. The results show that there is not a consistent relationship between cellular sensitivity and DNA DSB induction, a possible molecular mechanism of radiosensitivity which...

English Abstract

李文建, 周光明, 卫增泉, 王菊芳, 李强, 党秉荣, 颉红梅. 重离子辐射哺乳动物细胞敏感性的分子机理[J]. 原子核物理评论, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

引用本文:

李文建, 周光明, 卫增泉, 王菊芳, 李强, 党秉荣, 颉红梅. 重离子辐射哺乳动物细胞敏感性的分子机理[J]. 原子核物理评论, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

LI Wen-jian, ZHOU Guang-ming, WEI Zeng-quan, WANG Ju-fang, LI Qiang, DANG Bing-rong, XIE Hong-mei. A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions[J]. Nuclear Physics Review, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

Citation:

LI Wen-jian, ZHOU Guang-ming, WEI Zeng-quan, WANG Ju-fang, LI Qiang, DANG Bing-rong, XIE Hong-mei. A Possible Molecular Mechanism of Radiosensitivity in Mammalian Cells Exposed to Heavy Ions[J]. Nuclear Physics Review, 2003, 20(1): 42-47. doi: 10.11804/NuclPhysRev.20.01.042

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